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Crowdsourced mapping of unexplored target space of kinase inhibitors.
Cichońska A, Ravikumar B, Allaway RJ, Wan F, Park S, Isayev O, Li S, Mason M, Lamb A, Tanoli Z, Jeon M, Kim S, Popova M, Capuzzi S, Zeng J, Dang K, Koytiger G, Kang J, Wells CI, Willson TM; IDG-DREAM Drug-Kinase Binding Prediction Challenge Consortium; Oprea TI, Schlessinger A, Drewry DH, Stolovitzky G, Wennerberg K, Guinney J, Aittokallio T. Cichońska A, et al. Among authors: allaway rj. Nat Commun. 2021 Jun 3;12(1):3307. doi: 10.1038/s41467-021-23165-1. Nat Commun. 2021. PMID: 34083538 Free PMC article.
Crowdsourced identification of multi-target kinase inhibitors for RET- and TAU- based disease: The Multi-Targeting Drug DREAM Challenge.
Xiong Z, Jeon M, Allaway RJ, Kang J, Park D, Lee J, Jeon H, Ko M, Jiang H, Zheng M, Tan AC, Guo X; Multi-Targeting Drug DREAM Challenge Community; Dang KK, Tropsha A, Hecht C, Das TK, Carlson HA, Abagyan R, Guinney J, Schlessinger A, Cagan R. Xiong Z, et al. Among authors: allaway rj. PLoS Comput Biol. 2021 Sep 14;17(9):e1009302. doi: 10.1371/journal.pcbi.1009302. eCollection 2021 Sep. PLoS Comput Biol. 2021. PMID: 34520464 Free PMC article.
A community challenge for a pancancer drug mechanism of action inference from perturbational profile data.
Douglass EF Jr, Allaway RJ, Szalai B, Wang W, Tian T, Fernández-Torras A, Realubit R, Karan C, Zheng S, Pessia A, Tanoli Z, Jafari M, Wan F, Li S, Xiong Y, Duran-Frigola M, Bertoni M, Badia-I-Mompel P, Mateo L, Guitart-Pla O, Chung V; DREAM CTD-squared Pancancer Drug Activity Challenge Consortium; Tang J, Zeng J, Aloy P, Saez-Rodriguez J, Guinney J, Gerhard DS, Califano A. Douglass EF Jr, et al. Among authors: allaway rj. Cell Rep Med. 2022 Jan 18;3(1):100492. doi: 10.1016/j.xcrm.2021.100492. eCollection 2022 Jan 18. Cell Rep Med. 2022. PMID: 35106508 Free PMC article.
A Crowdsourcing Approach to Develop Machine Learning Models to Quantify Radiographic Joint Damage in Rheumatoid Arthritis.
Sun D, Nguyen TM, Allaway RJ, Wang J, Chung V, Yu TV, Mason M, Dimitrovsky I, Ericson L, Li H, Guan Y, Israel A, Olar A, Pataki BA, Stolovitzky G, Guinney J, Gulko PS, Frazier MB, Chen JY, Costello JC, Bridges SL Jr; RA2-DREAM Challenge Community. Sun D, et al. Among authors: allaway rj. JAMA Netw Open. 2022 Aug 1;5(8):e2227423. doi: 10.1001/jamanetworkopen.2022.27423. JAMA Netw Open. 2022. PMID: 36036935 Free PMC article.
Machine learning in rare disease.
Banerjee J, Taroni JN, Allaway RJ, Prasad DV, Guinney J, Greene C. Banerjee J, et al. Among authors: allaway rj. Nat Methods. 2023 Jun;20(6):803-814. doi: 10.1038/s41592-023-01886-z. Epub 2023 May 29. Nat Methods. 2023. PMID: 37248386 Review.
Spatiotemporal Loss of NF1 in Schwann Cell Lineage Leads to Different Types of Cutaneous Neurofibroma Susceptible to Modification by the Hippo Pathway.
Chen Z, Mo J, Brosseau JP, Shipman T, Wang Y, Liao CP, Cooper JM, Allaway RJ, Gosline SJC, Guinney J, Carroll TJ, Le LQ. Chen Z, et al. Among authors: allaway rj. Cancer Discov. 2019 Jan;9(1):114-129. doi: 10.1158/2159-8290.CD-18-0151. Epub 2018 Oct 22. Cancer Discov. 2019. PMID: 30348677 Free PMC article.
18 results