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Loss of TDP-43 oligomerization or RNA binding elicits distinct aggregation patterns.
Pérez-Berlanga M, Wiersma VI, Zbinden A, De Vos L, Wagner U, Foglieni C, Mallona I, Betz KM, Cléry A, Weber J, Guo Z, Rigort R, de Rossi P, Manglunia R, Tantardini E, Sahadevan S, Stach O, Hruska-Plochan M, Allain FH, Paganetti P, Polymenidou M. Pérez-Berlanga M, et al. Among authors: allain fh. EMBO J. 2023 Sep 4;42(17):e111719. doi: 10.15252/embj.2022111719. Epub 2023 Jul 11. EMBO J. 2023. PMID: 37431963 Free PMC article.
A solid beta-sheet structure is formed at the surface of FUS droplets during aging.
Emmanouilidis L, Bartalucci E, Kan Y, Ijavi M, Pérez ME, Afanasyev P, Boehringer D, Zehnder J, Parekh SH, Bonn M, Michaels TCT, Wiegand T, Allain FH. Emmanouilidis L, et al. Among authors: allain fh. Nat Chem Biol. 2024 Mar 11. doi: 10.1038/s41589-024-01573-w. Online ahead of print. Nat Chem Biol. 2024. PMID: 38467846
Specific protein-RNA interactions are mostly preserved in biomolecular condensates.
de Vries T, Novakovic M, Ni Y, Smok I, Inghelram C, Bikaki M, Sarnowski CP, Han Y, Emmanouilidis L, Padroni G, Leitner A, Allain FH. de Vries T, et al. Among authors: allain fh. Sci Adv. 2024 Mar 8;10(10):eadm7435. doi: 10.1126/sciadv.adm7435. Epub 2024 Mar 6. Sci Adv. 2024. PMID: 38446881 Free PMC article.
184 results