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The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα.
Nat Commun. 2019 Apr 5;10(1):1566. doi: 10.1038/s41467-019-09598-9.
Nat Commun. 2019.
PMID: 30952952
Free PMC article.
Class 3 phosphoinositide 3-kinase promotes hepatic glucocorticoid receptor stability and transcriptional activity.
Shibayama Y, Alkhoury C, Nemazanyy I, F Henneman N, Cagnard N, Girard M, Atsumi T, Panasyuk G.
Shibayama Y, et al. Among authors: alkhoury c.
Acta Physiol (Oxf). 2022 May;235(1):e13793. doi: 10.1111/apha.13793. Epub 2022 Feb 7.
Acta Physiol (Oxf). 2022.
PMID: 35094500
Free PMC article.
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ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity.
Fougerat A, Schoiswohl G, Polizzi A, Régnier M, Wagner C, Smati S, Fougeray T, Lippi Y, Lasserre F, Raho I, Melin V, Tramunt B, Métivier R, Sommer C, Benhamed F, Alkhoury C, Greulich F, Jouffe C, Emile A, Schupp M, Gourdy P, Dubot P, Levade T, Meynard D, Ellero-Simatos S, Gamet-Payrastre L, Panasyuk G, Uhlenhaut H, Amri EZ, Cruciani-Guglielmacci C, Postic C, Wahli W, Loiseau N, Montagner A, Langin D, Lass A, Guillou H.
Fougerat A, et al. Among authors: alkhoury c.
Cell Rep. 2022 Jun 7;39(10):110910. doi: 10.1016/j.celrep.2022.110910.
Cell Rep. 2022.
PMID: 35675775
Free article.
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Class 3 PI3K coactivates the circadian clock to promote rhythmic de novo purine synthesis.
Alkhoury C, Henneman NF, Petrenko V, Shibayama Y, Segaloni A, Gadault A, Nemazanyy I, Le Guillou E, Wolide AD, Antoniadou K, Tong X, Tamaru T, Ozawa T, Girard M, Hnia K, Lutter D, Dibner C, Panasyuk G.
Alkhoury C, et al.
Nat Cell Biol. 2023 Jul;25(7):975-988. doi: 10.1038/s41556-023-01171-3. Epub 2023 Jul 6.
Nat Cell Biol. 2023.
PMID: 37414850
Free PMC article.
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Nuclear envelope disruption triggers hallmarks of aging in lung alveolar macrophages.
De Silva NS, Siewiera J, Alkhoury C, Nader GPF, Nadalin F, de Azevedo K, Couty M, Izquierdo HM, Bhargava A, Conrad C, Maurin M, Antoniadou K, Fouillade C, Londono-Vallejo A, Behrendt R, Bertotti K, Serdjebi C, Lanthiez F, Gallwitz L, Saftig P, Herrero-Fernández B, Saez A, González-Granado JM, van Niel G, Boissonnas A, Piel M, Manel N.
De Silva NS, et al. Among authors: alkhoury c.
Nat Aging. 2023 Oct;3(10):1251-1268. doi: 10.1038/s43587-023-00488-w. Epub 2023 Sep 18.
Nat Aging. 2023.
PMID: 37723209
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