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Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib.
Coombes RC, Howell S, Lord SR, Kenny L, Mansi J, Mitri Z, Palmieri C, Chap LI, Richards P, Gradishar W, Sardesai S, Melear J, O'Shaughnessy J, Ward P, Chalasani P, Arkenau T, Baird RD, Jeselsohn R, Ali S, Clack G, Bahl A, McIntosh S, Krebs MG. Coombes RC, et al. Among authors: ali s. Nat Commun. 2023 Jul 24;14(1):4444. doi: 10.1038/s41467-023-40061-y. Nat Commun. 2023. PMID: 37488191 Free PMC article. Clinical Trial.
Preoperative gefitinib versus gefitinib and anastrozole in postmenopausal patients with oestrogen-receptor positive and epidermal-growth-factor-receptor-positive primary breast cancer: a double-blind placebo-controlled phase II randomised trial.
Polychronis A, Sinnett HD, Hadjiminas D, Singhal H, Mansi JL, Shivapatham D, Shousha S, Jiang J, Peston D, Barrett N, Vigushin D, Morrison K, Beresford E, Ali S, Slade MJ, Coombes RC. Polychronis A, et al. Among authors: ali s. Lancet Oncol. 2005 Jun;6(6):383-91. doi: 10.1016/S1470-2045(05)70176-5. Lancet Oncol. 2005. PMID: 15925816 Clinical Trial.
Dissecting the predictive value of MAPK/AKT/estrogen-receptor phosphorylation axis in primary breast cancer to treatment response for tamoxifen over exemestane: a Translational Report of the Intergroup Exemestane Study (IES)-PathIES.
Szijgyarto Z, Flach KD, Opdam M, Palmieri C, Linn SC, Wesseling J, Ali S, Bliss JM, Cheang MCU, Zwart W, Coombes RC. Szijgyarto Z, et al. Among authors: ali s. Breast Cancer Res Treat. 2019 May;175(1):149-163. doi: 10.1007/s10549-018-05110-x. Epub 2019 Jan 24. Breast Cancer Res Treat. 2019. PMID: 30680659 Free PMC article.
CDK7 inhibitors as anticancer drugs.
Sava GP, Fan H, Coombes RC, Buluwela L, Ali S. Sava GP, et al. Among authors: ali s. Cancer Metastasis Rev. 2020 Sep;39(3):805-823. doi: 10.1007/s10555-020-09885-8. Cancer Metastasis Rev. 2020. PMID: 32385714 Free PMC article. Review.
Circulating Tumor DNA Profiling From Breast Cancer Screening Through to Metastatic Disease.
Page K, Martinson LJ, Fernandez-Garcia D, Hills A, Gleason KLT, Gray MC, Rushton AJ, Nteliopoulos G, Hastings RK, Goddard K, Ions C, Parmar V, Primrose L, Openshaw MR, Guttery DS, Palmieri C, Ali S, Stebbing J, Coombes RC, Shaw JA. Page K, et al. Among authors: ali s. JCO Precis Oncol. 2021 Nov 24;5:PO.20.00522. doi: 10.1200/PO.20.00522. eCollection 2021. JCO Precis Oncol. 2021. PMID: 34849446 Free PMC article.
Shallow WGS of individual CTCs identifies actionable targets for informing treatment decisions in metastatic breast cancer.
Fernandez-Garcia D, Nteliopoulos G, Hastings RK, Rushton A, Page K, Allsopp RC, Ambasager B, Gleason K, Guttery DS, Ali S, Charles Coombes R, Shaw JA. Fernandez-Garcia D, et al. Among authors: ali s. Br J Cancer. 2022 Nov;127(10):1858-1864. doi: 10.1038/s41416-022-01962-9. Epub 2022 Sep 10. Br J Cancer. 2022. PMID: 36088510 Free PMC article.
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