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In vitro-in silico study on the influence of dose, fraction bioactivated and endpoint used on the relative potency value of pyrrolizidine alkaloid N-oxides compared to parent pyrrolizidine alkaloids.
Curr Res Toxicol. 2024 Mar 1;6:100160. doi: 10.1016/j.crtox.2024.100160. eCollection 2024.
Curr Res Toxicol. 2024.
PMID: 38469320
Free PMC article.
Physiologically-Based Kinetic Modeling Predicts Similar In Vivo Relative Potency of Senecionine N-Oxide for Rat and Human at Realistic Low Exposure Levels.
Widjaja F, Alhejji Y, Yangchen J, Wesseling S, Rietjens IMCM.
Widjaja F, et al. Among authors: alhejji y.
Mol Nutr Food Res. 2023 Feb;67(4):e2200293. doi: 10.1002/mnfr.202200293. Epub 2023 Jan 24.
Mol Nutr Food Res. 2023.
PMID: 36478522
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The Role of Kinetics as Key Determinant in Toxicity of Pyrrolizidine Alkaloids and Their N-Oxides.
Widjaja F, Alhejji Y, Rietjens IMCM.
Widjaja F, et al. Among authors: alhejji y.
Planta Med. 2022 Feb;88(2):130-143. doi: 10.1055/a-1582-9794. Epub 2021 Nov 5.
Planta Med. 2022.
PMID: 34741297
Free PMC article.
Review.
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