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T cells with dysfunctional mitochondria induce multimorbidity and premature senescence.
Desdín-Micó G, Soto-Heredero G, Aranda JF, Oller J, Carrasco E, Gabandé-Rodríguez E, Blanco EM, Alfranca A, Cussó L, Desco M, Ibañez B, Gortazar AR, Fernández-Marcos P, Navarro MN, Hernaez B, Alcamí A, Baixauli F, Mittelbrunn M. Desdín-Micó G, et al. Among authors: alfranca a. Science. 2020 Jun 19;368(6497):1371-1376. doi: 10.1126/science.aax0860. Epub 2020 May 21. Science. 2020. PMID: 32439659
Plasma membrane calcium ATPase isoform 4 inhibits vascular endothelial growth factor-mediated angiogenesis through interaction with calcineurin.
Baggott RR, Alfranca A, López-Maderuelo D, Mohamed TM, Escolano A, Oller J, Ornes BC, Kurusamy S, Rowther FB, Brown JE, Oceandy D, Cartwright EJ, Wang W, Gómez-del Arco P, Martínez-Martínez S, Neyses L, Redondo JM, Armesilla AL. Baggott RR, et al. Among authors: alfranca a. Arterioscler Thromb Vasc Biol. 2014 Oct;34(10):2310-20. doi: 10.1161/ATVBAHA.114.304363. Epub 2014 Aug 21. Arterioscler Thromb Vasc Biol. 2014. PMID: 25147342
C/EBPβ and Nuclear Factor of Activated T Cells Differentially Regulate Adamts-1 Induction by Stimuli Associated with Vascular Remodeling.
Oller J, Alfranca A, Méndez-Barbero N, Villahoz S, Lozano-Vidal N, Martín-Alonso M, Arroyo AG, Escolano A, Armesilla AL, Campanero MR, Redondo JM. Oller J, et al. Among authors: alfranca a. Mol Cell Biol. 2015 Oct;35(19):3409-22. doi: 10.1128/MCB.00494-15. Epub 2015 Jul 27. Mol Cell Biol. 2015. PMID: 26217013 Free PMC article.
IL-6 serum levels predict severity and response to tocilizumab in COVID-19: An observational study.
Galván-Román JM, Rodríguez-García SC, Roy-Vallejo E, Marcos-Jiménez A, Sánchez-Alonso S, Fernández-Díaz C, Alcaraz-Serna A, Mateu-Albero T, Rodríguez-Cortes P, Sánchez-Cerrillo I, Esparcia L, Martínez-Fleta P, López-Sanz C, Gabrie L, Del Campo Guerola L, Suárez-Fernández C, Ancochea J, Canabal A, Albert P, Rodríguez-Serrano DA, Aguilar JM, Del Arco C, de Los Santos I, García-Fraile L, de la Cámara R, Serra JM, Ramírez E, Alonso T, Landete P, Soriano JB, Martín-Gayo E, Fraile Torres A, Zurita Cruz ND, García-Vicuña R, Cardeñoso L, Sánchez-Madrid F, Alfranca A, Muñoz-Calleja C, González-Álvaro I; REINMUN-COVID Group. Galván-Román JM, et al. Among authors: alfranca a. J Allergy Clin Immunol. 2021 Jan;147(1):72-80.e8. doi: 10.1016/j.jaci.2020.09.018. Epub 2020 Sep 30. J Allergy Clin Immunol. 2021. PMID: 33010257 Free PMC article. Clinical Trial.
Intratumoral expression using a NFkB-based promoter enhances IL12 antitumor efficacy.
Garaulet G, Pérez-Chacon G, Alarcón H, Alfranca A, Mulero F, Martínez-Torrecuadrada J, Zapata JM, Rodríguez A. Garaulet G, et al. Among authors: alfranca a. Cancer Gene Ther. 2019 Jul;26(7-8):216-233. doi: 10.1038/s41417-018-0076-4. Epub 2019 Jan 9. Cancer Gene Ther. 2019. PMID: 30622324 Free article.
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