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A transcribed enhancer dictates mesendoderm specification in pluripotency.
Alexanian M, Maric D, Jenkinson SP, Mina M, Friedman CE, Ting CC, Micheletti R, Plaisance I, Nemir M, Maison D, Kernen J, Pezzuto I, Villeneuve D, Burdet F, Ibberson M, Leib SL, Palpant NJ, Hernandez N, Ounzain S, Pedrazzini T. Alexanian M, et al. Nat Commun. 2017 Nov 27;8(1):1806. doi: 10.1038/s41467-017-01804-w. Nat Commun. 2017. PMID: 29180618 Free PMC article.
Genome-wide profiling of the cardiac transcriptome after myocardial infarction identifies novel heart-specific long non-coding RNAs.
Ounzain S, Micheletti R, Beckmann T, Schroen B, Alexanian M, Pezzuto I, Crippa S, Nemir M, Sarre A, Johnson R, Dauvillier J, Burdet F, Ibberson M, Guigó R, Xenarios I, Heymans S, Pedrazzini T. Ounzain S, et al. Among authors: alexanian m. Eur Heart J. 2015 Feb 7;36(6):353-68a. doi: 10.1093/eurheartj/ehu180. Epub 2014 Apr 30. Eur Heart J. 2015. PMID: 24786300 Free PMC article.
Functional importance of cardiac enhancer-associated noncoding RNAs in heart development and disease.
Ounzain S, Pezzuto I, Micheletti R, Burdet F, Sheta R, Nemir M, Gonzales C, Sarre A, Alexanian M, Blow MJ, May D, Johnson R, Dauvillier J, Pennacchio LA, Pedrazzini T. Ounzain S, et al. Among authors: alexanian m. J Mol Cell Cardiol. 2014 Nov;76:55-70. doi: 10.1016/j.yjmcc.2014.08.009. Epub 2014 Aug 19. J Mol Cell Cardiol. 2014. PMID: 25149110 Free PMC article.
CARMEN, a human super enhancer-associated long noncoding RNA controlling cardiac specification, differentiation and homeostasis.
Ounzain S, Micheletti R, Arnan C, Plaisance I, Cecchi D, Schroen B, Reverter F, Alexanian M, Gonzales C, Ng SY, Bussotti G, Pezzuto I, Notredame C, Heymans S, Guigó R, Johnson R, Pedrazzini T. Ounzain S, et al. Among authors: alexanian m. J Mol Cell Cardiol. 2015 Dec;89(Pt A):98-112. doi: 10.1016/j.yjmcc.2015.09.016. Epub 2015 Sep 28. J Mol Cell Cardiol. 2015. PMID: 26423156 Free article.
New Lncs to mesendoderm specification.
Alexanian M, Pedrazzini T, Ounzain S. Alexanian M, et al. J Thorac Dis. 2017 Mar;9(Suppl 1):S5-S8. doi: 10.21037/jtd.2017.03.70. J Thorac Dis. 2017. PMID: 28446963 Free PMC article. Review.
The long noncoding RNA Wisper controls cardiac fibrosis and remodeling.
Micheletti R, Plaisance I, Abraham BJ, Sarre A, Ting CC, Alexanian M, Maric D, Maison D, Nemir M, Young RA, Schroen B, González A, Ounzain S, Pedrazzini T. Micheletti R, et al. Among authors: alexanian m. Sci Transl Med. 2017 Jun 21;9(395):eaai9118. doi: 10.1126/scitranslmed.aai9118. Sci Transl Med. 2017. PMID: 28637928 Free PMC article.
Long Noncoding RNAs in Cardiac Development.
Alexanian M, Ounzain S. Alexanian M, et al. Cold Spring Harb Perspect Biol. 2020 Nov 2;12(11):a037374. doi: 10.1101/cshperspect.a037374. Cold Spring Harb Perspect Biol. 2020. PMID: 31932317 Free PMC article. Review.
Conserved Epigenetic Regulatory Logic Infers Genes Governing Cell Identity.
Shim WJ, Sinniah E, Xu J, Vitrinel B, Alexanian M, Andreoletti G, Shen S, Sun Y, Balderson B, Boix C, Peng G, Jing N, Wang Y, Kellis M, Tam PPL, Smith A, Piper M, Christiaen L, Nguyen Q, Bodén M, Palpant NJ. Shim WJ, et al. Among authors: alexanian m. Cell Syst. 2020 Dec 16;11(6):625-639.e13. doi: 10.1016/j.cels.2020.11.001. Epub 2020 Dec 4. Cell Syst. 2020. PMID: 33278344 Free PMC article.
A transcriptional switch governs fibroblast activation in heart disease.
Alexanian M, Przytycki PF, Micheletti R, Padmanabhan A, Ye L, Travers JG, Gonzalez-Teran B, Silva AC, Duan Q, Ranade SS, Felix F, Linares-Saldana R, Li L, Lee CY, Sadagopan N, Pelonero A, Huang Y, Andreoletti G, Jain R, McKinsey TA, Rosenfeld MG, Gifford CA, Pollard KS, Haldar SM, Srivastava D. Alexanian M, et al. Nature. 2021 Jul;595(7867):438-443. doi: 10.1038/s41586-021-03674-1. Epub 2021 Jun 23. Nature. 2021. PMID: 34163071 Free PMC article.
Transcriptional plasticity of fibroblasts in heart disease.
Micheletti R, Alexanian M. Micheletti R, et al. Among authors: alexanian m. Biochem Soc Trans. 2022 Oct 31;50(5):1247-1255. doi: 10.1042/BST20210864. Biochem Soc Trans. 2022. PMID: 36281993 Free PMC article. Review.
27 results