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IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease.
Ma HY, Yamamoto G, Xu J, Liu X, Karin D, Kim JY, Alexandrov LB, Koyama Y, Nishio T, Benner C, Heinz S, Rosenthal SB, Liang S, Sun M, Karin G, Zhao P, Brodt P, Mckillop IH, Quehenberger O, Dennis E, Saltiel A, Tsukamoto H, Gao B, Karin M, Brenner DA, Kisseleva T. Ma HY, et al. Among authors: alexandrov lb. J Hepatol. 2020 May;72(5):946-959. doi: 10.1016/j.jhep.2019.12.016. Epub 2019 Dec 31. J Hepatol. 2020. PMID: 31899206 Free PMC article.
Integrative genomic analysis of mouse and human hepatocellular carcinoma.
Dow M, Pyke RM, Tsui BY, Alexandrov LB, Nakagawa H, Taniguchi K, Seki E, Harismendy O, Shalapour S, Karin M, Carter H, Font-Burgada J. Dow M, et al. Among authors: alexandrov lb. Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):E9879-E9888. doi: 10.1073/pnas.1811029115. Epub 2018 Oct 4. Proc Natl Acad Sci U S A. 2018. PMID: 30287485 Free PMC article.
Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4.
Wang Z, Wu VH, Allevato MM, Gilardi M, He Y, Luis Callejas-Valera J, Vitale-Cross L, Martin D, Amornphimoltham P, Mcdermott J, Yung BS, Goto Y, Molinolo AA, Sharabi AB, Cohen EEW, Chen Q, Lyons JG, Alexandrov LB, Gutkind JS. Wang Z, et al. Among authors: alexandrov lb. Nat Commun. 2019 Dec 5;10(1):5546. doi: 10.1038/s41467-019-13471-0. Nat Commun. 2019. PMID: 31804466 Free PMC article.
Inflammation-driven deaminase deregulation fuels human pre-leukemia stem cell evolution.
Jiang Q, Isquith J, Ladel L, Mark A, Holm F, Mason C, He Y, Mondala P, Oliver I, Pham J, Ma W, Reynoso E, Ali S, Morris IJ, Diep R, Nasamran C, Xu G, Sasik R, Rosenthal SB, Birmingham A, Coso S, Pineda G, Crews L, Donohoe ME, Venter JC, Whisenant T, Mesa RA, Alexandrov LB, Fisch KM, Jamieson C. Jiang Q, et al. Among authors: alexandrov lb. Cell Rep. 2021 Jan 26;34(4):108670. doi: 10.1016/j.celrep.2020.108670. Cell Rep. 2021. PMID: 33503434 Free PMC article.
Strength of immune selection in tumors varies with sex and age.
Castro A, Pyke RM, Zhang X, Thompson WK, Day CP, Alexandrov LB, Zanetti M, Carter H. Castro A, et al. Among authors: alexandrov lb. Nat Commun. 2020 Aug 17;11(1):4128. doi: 10.1038/s41467-020-17981-0. Nat Commun. 2020. PMID: 32807809 Free PMC article.
Sex differences in oncogenic mutational processes.
Li CH, Prokopec SD, Sun RX, Yousif F, Schmitz N; PCAWG Tumour Subtypes and Clinical Translation; Boutros PC; PCAWG Consortium. Li CH, et al. Nat Commun. 2020 Aug 28;11(1):4330. doi: 10.1038/s41467-020-17359-2. Nat Commun. 2020. PMID: 32859912 Free PMC article.
Synchronous, Yet Genomically Distinct, GIST Offer New Insights Into Precise Targeting of Tumor Driver Mutations.
Makris EA, Sharma AK, Bergstrom EN, Xu X, de la Torre J, Banerjee S, Nguyen V, Hosseini M, Burgoyne A, Harismendy O, Alexandrov LB, Sicklick JK. Makris EA, et al. Among authors: alexandrov lb. JCO Precis Oncol. 2021 Mar 19;5:PO.20.00384. doi: 10.1200/PO.20.00384. eCollection 2021. JCO Precis Oncol. 2021. PMID: 34250403 Free PMC article. No abstract available.
206 results