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Elongation of N6-benzyladenosine scaffold via Pd-catalyzed C-C bond formation leads to derivatives with antiflaviviral activity.
Zenchenko AA, Drenichev MS, Khvatov EV, Uvarova VI, Goryashchenko AS, Frolenko VS, Karpova EV, Kozlovskaya LI, Osolodkin DI, Ishmukhametov AA, Mikhailov SN, Oslovsky VE. Zenchenko AA, et al. Among authors: goryashchenko as. Bioorg Med Chem. 2024 Jan 15;98:117552. doi: 10.1016/j.bmc.2023.117552. Epub 2023 Dec 10. Bioorg Med Chem. 2024. PMID: 38128296
3-[N,N-Bis(sulfonyl)amino]isoxazolines with Spiro-Annulated or 1,2-Annulated Cyclooctane Rings Inhibit Reproduction of Tick-Borne Encephalitis, Yellow Fever, and West Nile Viruses.
Sedenkova KN, Sazonov AS, Vasilenko DA, Andriasov KS, Eremenko MG, Grishin YK, Khvatov EV, Goryashchenko AS, Uvarova VI, Osolodkin DI, Ishmukhametov AA, Averina EB. Sedenkova KN, et al. Among authors: goryashchenko as. Int J Mol Sci. 2023 Jun 28;24(13):10758. doi: 10.3390/ijms241310758. Int J Mol Sci. 2023. PMID: 37445937 Free PMC article.
Tetrahydroquinazoline N-oxide derivatives inhibit reproduction of tick-borne and mosquito-borne flaviviruses.
Sedenkova KN, Uvarova VI, Nazarova AA, Peisikova AV, Khvatov EV, Sukhorukov MV, Frolenko VS, Goryashchenko AS, Kholodilov IS, Grishin YK, Rybakov VB, Makenov MT, Morozkin ES, Karan LS, Kozlovskaya LI, Ishmukhametov AA, Osolodkin DI, Averina EB. Sedenkova KN, et al. Among authors: goryashchenko as. Arch Pharm (Weinheim). 2023 Jul;356(7):e2300027. doi: 10.1002/ardp.202300027. Epub 2023 May 3. Arch Pharm (Weinheim). 2023. PMID: 37138375
The dimeric ectodomain of the alkali-sensing insulin receptor-related receptor (ectoIRR) has a droplike shape.
Shtykova EV, Petoukhov MV, Mozhaev AA, Deyev IE, Dadinova LA, Loshkarev NA, Goryashchenko AS, Bocharov EV, Jeffries CM, Svergun DI, Batishchev OV, Petrenko AG. Shtykova EV, et al. Among authors: goryashchenko as. J Biol Chem. 2019 Nov 22;294(47):17790-17798. doi: 10.1074/jbc.RA119.010390. Epub 2019 Oct 15. J Biol Chem. 2019. PMID: 31615897 Free PMC article.
11 results