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Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains.
Wang J, Erazo T, Ferguson FM, Buckley DL, Gomez N, Muñoz-Guardiola P, Diéguez-Martínez N, Deng X, Hao M, Massefski W, Fedorov O, Offei-Addo NK, Park PM, Dai L, DiBona A, Becht K, Kim ND, McKeown MR, Roberts JM, Zhang J, Sim T, Alessi DR, Bradner JE, Lizcano JM, Blacklow SC, Qi J, Xu X, Gray NS. Wang J, et al. Among authors: alessi dr. ACS Chem Biol. 2018 Sep 21;13(9):2438-2448. doi: 10.1021/acschembio.7b00638. Epub 2018 Aug 31. ACS Chem Biol. 2018. PMID: 30102854 Free PMC article.
Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth.
Sapkota GP, Kieloch A, Lizcano JM, Lain S, Arthur JS, Williams MR, Morrice N, Deak M, Alessi DR. Sapkota GP, et al. Among authors: alessi dr. J Biol Chem. 2001 Jun 1;276(22):19469-82. doi: 10.1074/jbc.M009953200. Epub 2001 Jan 31. J Biol Chem. 2001. PMID: 11297520 Free article.
The insulin signalling pathway.
Lizcano JM, Alessi DR. Lizcano JM, et al. Among authors: alessi dr. Curr Biol. 2002 Apr 2;12(7):R236-8. doi: 10.1016/s0960-9822(02)00777-7. Curr Biol. 2002. PMID: 11937037 Free article. Review. No abstract available.
Molecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivo.
Lizcano JM, Deak M, Morrice N, Kieloch A, Hastie CJ, Dong L, Schutkowski M, Reimer U, Alessi DR. Lizcano JM, et al. Among authors: alessi dr. J Biol Chem. 2002 Aug 2;277(31):27839-49. doi: 10.1074/jbc.M202042200. Epub 2002 May 22. J Biol Chem. 2002. PMID: 12023960 Free article.
The selectivity of protein kinase inhibitors: a further update.
Bain J, Plater L, Elliott M, Shpiro N, Hastie CJ, McLauchlan H, Klevernic I, Arthur JS, Alessi DR, Cohen P. Bain J, et al. Among authors: alessi dr. Biochem J. 2007 Dec 15;408(3):297-315. doi: 10.1042/BJ20070797. Biochem J. 2007. PMID: 17850214 Free PMC article.
311 results