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Effect of Stress Ulcer Prophylaxis With Proton Pump Inhibitors vs Histamine-2 Receptor Blockers on In-Hospital Mortality Among ICU Patients Receiving Invasive Mechanical Ventilation: The PEPTIC Randomized Clinical Trial.
PEPTIC Investigators for the Australian and New Zealand Intensive Care Society Clinical Trials Group, Alberta Health Services Critical Care Strategic Clinical Network, and the Irish Critical Care Trials Group; Young PJ, Bagshaw SM, Forbes AB, Nichol AD, Wright SE, Bailey M, Bellomo R, Beasley R, Brickell K, Eastwood GM, Gattas DJ, van Haren F, Litton E, Mackle DM, McArthur CJ, McGuinness SP, Mouncey PR, Navarra L, Opgenorth D, Pilcher D, Saxena MK, Webb SA, Wiley D, Rowan KM. PEPTIC Investigators for the Australian and New Zealand Intensive Care Society Clinical Trials Group, Alberta Health Services Critical Care Strategic Clinical Network, and the Irish Critical Care Trials Group, et al. JAMA. 2020 Feb 18;323(7):616-626. doi: 10.1001/jama.2019.22190. JAMA. 2020. PMID: 31950977 Free PMC article. Clinical Trial.
Protocol and statistical analysis plan for the mega randomised registry trial research program comparing conservative versus liberal oxygenation targets in adults receiving unplanned invasive mechanical ventilation in the ICU (Mega-ROX).
Young PJ, Arabi YM, Bagshaw SM, Bellomo R, Fujii T, Haniffa R, Hodgson CL, Vijayaraghavan BKT, Litton E, Mackle D, Nichol AD, Kasza J; Mega-ROX Management Committee; Australian and New Zealand Intensive Care Society Clinical Trials Group; Crit Care Asia and Africa Network; Irish Critical Care Clinical Trials Group; Alberta Health Services Critical Care Strategic Clinical Network. Young PJ, et al. Crit Care Resusc. 2023 Oct 19;24(2):137-149. doi: 10.51893/2022.2.OA4. eCollection 2022 Jun 6. Crit Care Resusc. 2023. PMID: 38045600 Free PMC article.