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Human radical scavenger α1-microglobulin protects against hemolysis in vitro and α1-microglobulin knockout mice exhibit a macrocytic anemia phenotype.
Kristiansson A, Bergwik J, Alattar AG, Flygare J, Gram M, Hansson SR, Olsson ML, Storry JR, Allhorn M, Åkerström B. Kristiansson A, et al. Among authors: alattar ag. Free Radic Biol Med. 2021 Jan;162:149-159. doi: 10.1016/j.freeradbiomed.2020.02.018. Epub 2020 Feb 21. Free Radic Biol Med. 2021. PMID: 32092412
Yippee like 4 (Ypel4) is essential for normal mouse red blood cell membrane integrity.
Mattebo A, Sen T, Jassinskaja M, Pimková K, Prieto González-Albo I, Alattar AG, Ramakrishnan R, Lang S, Järås M, Hansson J, Soneji S, Singbrant S, van den Akker E, Flygare J. Mattebo A, et al. Among authors: alattar ag. Sci Rep. 2021 Aug 5;11(1):15898. doi: 10.1038/s41598-021-95291-1. Sci Rep. 2021. PMID: 34354145 Free PMC article.
Targeting elevated heme levels to treat a mouse model for Diamond-Blackfan Anemia.
Sjögren SE, Chen J, Mattebo A, Alattar AG, Karlsson H, Siva K, Soneji S, Tedgård U, Chen JJ, Gram M, Flygare J. Sjögren SE, et al. Among authors: alattar ag. Exp Hematol. 2022 Jan;105:50-61. doi: 10.1016/j.exphem.2021.10.005. Epub 2021 Oct 30. Exp Hematol. 2022. PMID: 34757171 Free PMC article.
Disruption of the tumour-associated EMP3 enhances erythroid proliferation and causes the MAM-negative phenotype.
Thornton N, Karamatic Crew V, Tilley L, Green CA, Tay CL, Griffiths RE, Singleton BK, Spring F, Walser P, Alattar AG, Jones B, Laundy R, Storry JR, Möller M, Wall L, Charlewood R, Westhoff CM, Lomas-Francis C, Yahalom V, Feick U, Seltsam A, Mayer B, Olsson ML, Anstee DJ. Thornton N, et al. Among authors: alattar ag. Nat Commun. 2020 Jul 16;11(1):3569. doi: 10.1038/s41467-020-17060-4. Nat Commun. 2020. PMID: 32678083 Free PMC article.
Ciclopirox ethanolamine preserves the immature state of human HSCs by mediating intracellular iron content.
Talkhoncheh MS, Baudet A, Ek F, Subramaniam A, Kao YR, Miharada N, Karlsson C, Oburoglu L, Rydström A, Zemaitis K, Alattar AG, Rak J, Pietras K, Olsson R, Will B, Larsson J. Talkhoncheh MS, et al. Among authors: alattar ag. Blood Adv. 2023 Dec 26;7(24):7407-7417. doi: 10.1182/bloodadvances.2023009844. Blood Adv. 2023. PMID: 37487020 Free PMC article.