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The ever-evolving role of mTOR in translation.
Fonseca BD, Smith EM, Yelle N, Alain T, Bushell M, Pause A. Fonseca BD, et al. Among authors: alain t. Semin Cell Dev Biol. 2014 Dec;36:102-12. doi: 10.1016/j.semcdb.2014.09.014. Epub 2014 Sep 27. Semin Cell Dev Biol. 2014. PMID: 25263010 Review.
La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1).
Fonseca BD, Zakaria C, Jia JJ, Graber TE, Svitkin Y, Tahmasebi S, Healy D, Hoang HD, Jensen JM, Diao IT, Lussier A, Dajadian C, Padmanabhan N, Wang W, Matta-Camacho E, Hearnden J, Smith EM, Tsukumo Y, Yanagiya A, Morita M, Petroulakis E, González JL, Hernández G, Alain T, Damgaard CK. Fonseca BD, et al. Among authors: alain t. J Biol Chem. 2015 Jun 26;290(26):15996-6020. doi: 10.1074/jbc.M114.621730. Epub 2015 May 4. J Biol Chem. 2015. PMID: 25940091 Free PMC article.
S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3.
Wang F, Alain T, Szretter KJ, Stephenson K, Pol JG, Atherton MJ, Hoang HD, Fonseca BD, Zakaria C, Chen L, Rangwala Z, Hesch A, Chan ESY, Tuinman C, Suthar MS, Jiang Z, Ashkar AA, Thomas G, Kozma SC, Gale M Jr, Fitzgerald KA, Diamond MS, Mossman K, Sonenberg N, Wan Y, Lichty BD. Wang F, et al. Among authors: alain t. Nat Immunol. 2016 May;17(5):514-522. doi: 10.1038/ni.3433. Epub 2016 Apr 4. Nat Immunol. 2016. PMID: 27043414 Free PMC article.
UPF1 Governs Synaptic Plasticity through Association with a STAU2 RNA Granule.
Graber TE, Freemantle E, Anadolu MN, Hébert-Seropian S, MacAdam RL, Shin U, Hoang HD, Alain T, Lacaille JC, Sossin WS. Graber TE, et al. Among authors: alain t. J Neurosci. 2017 Sep 20;37(38):9116-9131. doi: 10.1523/JNEUROSCI.0088-17.2017. Epub 2017 Aug 18. J Neurosci. 2017. PMID: 28821679 Free PMC article.
Metformin requires 4E-BPs to induce apoptosis and repress translation of Mcl-1 in hepatocellular carcinoma cells.
Bhat M, Yanagiya A, Graber T, Razumilava N, Bronk S, Zammit D, Zhao Y, Zakaria C, Metrakos P, Pollak M, Sonenberg N, Gores G, Jaramillo M, Morita M, Alain T. Bhat M, et al. Among authors: alain t. Oncotarget. 2016 Jul 18;8(31):50542-50556. doi: 10.18632/oncotarget.10671. eCollection 2017 Aug 1. Oncotarget. 2016. PMID: 28881582 Free PMC article.
eIF4E-Binding Proteins 1 and 2 Limit Macrophage Anti-Inflammatory Responses through Translational Repression of IL-10 and Cyclooxygenase-2.
William M, Leroux LP, Chaparro V, Lorent J, Graber TE, M'Boutchou MN, Charpentier T, Fabié A, Dozois CM, Stäger S, van Kempen LC, Alain T, Larsson O, Jaramillo M. William M, et al. Among authors: alain t. J Immunol. 2018 Jun 15;200(12):4102-4116. doi: 10.4049/jimmunol.1701670. Epub 2018 Apr 30. J Immunol. 2018. PMID: 29712774
Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis.
Zakaria C, Sean P, Hoang HD, Leroux LP, Watson M, Workenhe ST, Hearnden J, Pearl D, Truong VT, Robichaud N, Yanagiya A, Tahmasebi S, Jafarnejad SM, Jia JJ, Pelin A, Diallo JS, Le Boeuf F, Bell JC, Mossman KL, Graber TE, Jaramillo M, Sonenberg N, Alain T. Zakaria C, et al. Among authors: alain t. PLoS Pathog. 2018 Aug 23;14(8):e1007264. doi: 10.1371/journal.ppat.1007264. eCollection 2018 Aug. PLoS Pathog. 2018. PMID: 30138450 Free PMC article.
112 results