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A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models.
Ren F, Aliper A, Chen J, Zhao H, Rao S, Kuppe C, Ozerov IV, Zhang M, Witte K, Kruse C, Aladinskiy V, Ivanenkov Y, Polykovskiy D, Fu Y, Babin E, Qiao J, Liang X, Mou Z, Wang H, Pun FW, Ayuso PT, Veviorskiy A, Song D, Liu S, Zhang B, Naumov V, Ding X, Kukharenko A, Izumchenko E, Zhavoronkov A. Ren F, et al. Among authors: aladinskiy v. Nat Biotechnol. 2024 Mar 8. doi: 10.1038/s41587-024-02143-0. Online ahead of print. Nat Biotechnol. 2024. PMID: 38459338
AlphaFold accelerates artificial intelligence powered drug discovery: efficient discovery of a novel CDK20 small molecule inhibitor.
Ren F, Ding X, Zheng M, Korzinkin M, Cai X, Zhu W, Mantsyzov A, Aliper A, Aladinskiy V, Cao Z, Kong S, Long X, Man Liu BH, Liu Y, Naumov V, Shneyderman A, Ozerov IV, Wang J, Pun FW, Polykovskiy DA, Sun C, Levitt M, Aspuru-Guzik A, Zhavoronkov A. Ren F, et al. Among authors: aladinskiy v. Chem Sci. 2023 Jan 10;14(6):1443-1452. doi: 10.1039/d2sc05709c. eCollection 2023 Feb 8. Chem Sci. 2023. PMID: 36794205 Free PMC article.
Chemistry42: An AI-Driven Platform for Molecular Design and Optimization.
Ivanenkov YA, Polykovskiy D, Bezrukov D, Zagribelnyy B, Aladinskiy V, Kamya P, Aliper A, Ren F, Zhavoronkov A. Ivanenkov YA, et al. Among authors: aladinskiy v. J Chem Inf Model. 2023 Feb 13;63(3):695-701. doi: 10.1021/acs.jcim.2c01191. Epub 2023 Feb 2. J Chem Inf Model. 2023. PMID: 36728505 Free PMC article.
Molecular Sets (MOSES): A Benchmarking Platform for Molecular Generation Models.
Polykovskiy D, Zhebrak A, Sanchez-Lengeling B, Golovanov S, Tatanov O, Belyaev S, Kurbanov R, Artamonov A, Aladinskiy V, Veselov M, Kadurin A, Johansson S, Chen H, Nikolenko S, Aspuru-Guzik A, Zhavoronkov A. Polykovskiy D, et al. Among authors: aladinskiy v. Front Pharmacol. 2020 Dec 18;11:565644. doi: 10.3389/fphar.2020.565644. eCollection 2020. Front Pharmacol. 2020. PMID: 33390943 Free PMC article.
Synthesis, inhibitory activity and oral dosing formulation of AV5124, the structural analogue of influenza virus endonuclease inhibitor baloxavir.
Ivashchenko AA, Mitkin OD, Jones JC, Nikitin AV, Koryakova AG, Karapetian RN, Kravchenko DV, Mochalov SV, Ryakhovskiy AA, Aladinskiy V, Leneva IA, Falynskova IN, Glubokova EA, Govorkova EA, Ivachtchenko AV. Ivashchenko AA, et al. Among authors: aladinskiy v. J Antimicrob Chemother. 2021 Mar 12;76(4):1010-1018. doi: 10.1093/jac/dkaa524. J Antimicrob Chemother. 2021. PMID: 33367751 Free PMC article.
Non-rigid Diarylmethyl Analogs of Baloxavir as Cap-Dependent Endonuclease Inhibitors of Influenza Viruses.
Ivashchenko AA, Mitkin OD, Jones JC, Nikitin AV, Koryakova AG, Ryakhovskiy A, Karapetian RN, Kravchenko DV, Aladinskiy V, Leneva IA, Falynskova IN, Glubokova EA, Govorkova EA, Ivachtchenko AV. Ivashchenko AA, et al. Among authors: aladinskiy v. J Med Chem. 2020 Sep 10;63(17):9403-9420. doi: 10.1021/acs.jmedchem.0c00565. Epub 2020 Aug 17. J Med Chem. 2020. PMID: 32787099
Synthesis and biological activity of 5-aryliden-2-thiohydantoin S-aryl derivatives.
Finko AV, Skvortsov DA, Laikov DN, Averochkin GM, Dlin EA, Kalinina MA, Aladinskiy VA, Vorobyeva NS, Mironov AV, Beloglazkina EK, Zyk NV, Ivanenkov YA, Majouga AG. Finko AV, et al. Among authors: aladinskiy va. Bioorg Chem. 2020 Jul;100:103900. doi: 10.1016/j.bioorg.2020.103900. Epub 2020 May 11. Bioorg Chem. 2020. PMID: 32428745
Substituted Furanocoumarins as Novel Class of Antibacterial Translation Inhibitors.
Ivanenkov YA, Yamidanov RS, Osterman IA, Sergiev PV, Ayginin AA, Aladinskiy VA, Aladinskaya AV, Terentiev VA, Veselov MS, Skvortsov DA, Komarova KS, Chemeris AV, Zainullina LF, Maximova MA, Zileeva ZR, Vakhitova YV, Baymiev AK, Baymiev AK, Sofronova AA, Machulkin AE, Petrov RA, Bezrukov DS, Puchinina MM, Lukianov DA, Dontsova OA. Ivanenkov YA, et al. Among authors: aladinskiy va. Comb Chem High Throughput Screen. 2019;22(6):400-410. doi: 10.2174/1386207322666190723110539. Comb Chem High Throughput Screen. 2019. PMID: 31573876
25 results