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Novel methodologies for biomarker discovery in atherosclerosis.
Hoefer IE, Steffens S, Ala-Korpela M, Bäck M, Badimon L, Bochaton-Piallat ML, Boulanger CM, Caligiuri G, Dimmeler S, Egido J, Evans PC, Guzik T, Kwak BR, Landmesser U, Mayr M, Monaco C, Pasterkamp G, Tuñón J, Weber C; ESC Working Group Atherosclerosis and Vascular Biology. Hoefer IE, et al. Eur Heart J. 2015 Oct 14;36(39):2635-42. doi: 10.1093/eurheartj/ehv236. Epub 2015 Jun 5. Eur Heart J. 2015. PMID: 26049157 Review.
High-throughput quantification of circulating metabolites improves prediction of subclinical atherosclerosis.
Würtz P, Raiko JR, Magnussen CG, Soininen P, Kangas AJ, Tynkkynen T, Thomson R, Laatikainen R, Savolainen MJ, Laurikka J, Kuukasjärvi P, Tarkka M, Karhunen PJ, Jula A, Viikari JS, Kähönen M, Lehtimäki T, Juonala M, Ala-Korpela M, Raitakari OT. Würtz P, et al. Eur Heart J. 2012 Sep;33(18):2307-16. doi: 10.1093/eurheartj/ehs020. Epub 2012 Mar 26. Eur Heart J. 2012. PMID: 22450427
Nuclear magnetic resonance-based metabolomics identifies phenylalanine as a novel predictor of incident heart failure hospitalisation: results from PROSPER and FINRISK 1997.
Delles C, Rankin NJ, Boachie C, McConnachie A, Ford I, Kangas A, Soininen P, Trompet S, Mooijaart SP, Jukema JW, Zannad F, Ala-Korpela M, Salomaa V, Havulinna AS, Welsh P, Würtz P, Sattar N. Delles C, et al. Eur J Heart Fail. 2018 Apr;20(4):663-673. doi: 10.1002/ejhf.1076. Epub 2017 Dec 11. Eur J Heart Fail. 2018. PMID: 29226610 Free PMC article. Clinical Trial.
Metabolic Biomarker Discovery for Risk of Peripheral Artery Disease Compared With Coronary Artery Disease: Lipoprotein and Metabolite Profiling of 31 657 Individuals From 5 Prospective Cohorts.
Tikkanen E, Jägerroos V, Holmes MV, Sattar N, Ala-Korpela M, Jousilahti P, Lundqvist A, Perola M, Salomaa V, Würtz P. Tikkanen E, et al. J Am Heart Assoc. 2021 Dec 7;10(23):e021995. doi: 10.1161/JAHA.121.021995. Epub 2021 Nov 30. J Am Heart Assoc. 2021. PMID: 34845932 Free PMC article.
Glycoprotein Acetyls: A Novel Inflammatory Biomarker of Early Cardiovascular Risk in the Young.
Chiesa ST, Charakida M, Georgiopoulos G, Roberts JD, Stafford SJ, Park C, Mykkänen J, Kähönen M, Lehtimäki T, Ala-Korpela M, Raitakari O, Pietiäinen M, Pussinen P, Muthurangu V, Hughes AD, Sattar N, Timpson NJ, Deanfield JE. Chiesa ST, et al. J Am Heart Assoc. 2022 Feb 15;11(4):e024380. doi: 10.1161/JAHA.121.024380. Epub 2022 Feb 12. J Am Heart Assoc. 2022. PMID: 35156387 Free PMC article.
Variant rs10911021 that associates with coronary heart disease in type 2 diabetes, is associated with lower concentrations of circulating HDL cholesterol and large HDL particles but not with amino acids.
Beaney KE, Cooper JA, McLachlan S, Wannamethee SG, Jefferis BJ, Whincup P, Ben-Shlomo Y, Price JF, Kumari M, Wong A, Ong K, Hardy R, Kuh D, Kivimaki M, Kangas AJ, Soininen P, Ala-Korpela M, Drenos F, Humphries SE; UCLEB consortium. Beaney KE, et al. Cardiovasc Diabetol. 2016 Aug 22;15(1):115. doi: 10.1186/s12933-016-0435-0. Cardiovasc Diabetol. 2016. PMID: 27549350 Free PMC article.
266 results