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Midkine rewires the melanoma microenvironment toward a tolerogenic and immune-resistant state.
Cerezo-Wallis D, Contreras-Alcalde M, Troulé K, Catena X, Mucientes C, Calvo TG, Cañón E, Tejedo C, Pennacchi PC, Hogan S, Kölblinger P, Tejero H, Chen AX, Ibarz N, Graña-Castro O, Martinez L, Muñoz J, Ortiz-Romero P, Rodriguez-Peralto JL, Gómez-López G, Al-Shahrour F, Rabadán R, Levesque MP, Olmeda D, Soengas MS. Cerezo-Wallis D, et al. Nat Med. 2020 Dec;26(12):1865-1877. doi: 10.1038/s41591-020-1073-3. Epub 2020 Oct 19. Nat Med. 2020. PMID: 33077955
Functional signatures identified in B-cell non-Hodgkin lymphoma profiles.
Aggarwal M, Sánchez-Beato M, Gómez-López G, Al-Shahrour F, Martínez N, Rodríguez A, Ruiz-Ballesteros E, Camacho FI, Pérez-Rosado A, de la Cueva P, Artiga MJ, Pisano DG, Kimby E, Dopazo J, Villuendas R, Piris MA. Aggarwal M, et al. Leuk Lymphoma. 2009 Oct;50(10):1699-708. doi: 10.1080/10428190903189035. Leuk Lymphoma. 2009. PMID: 19863341
Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML.
Puram RV, Kowalczyk MS, de Boer CG, Schneider RK, Miller PG, McConkey M, Tothova Z, Tejero H, Heckl D, Järås M, Chen MC, Li H, Tamayo A, Cowley GS, Rozenblatt-Rosen O, Al-Shahrour F, Regev A, Ebert BL. Puram RV, et al. Cell. 2016 Apr 7;165(2):303-16. doi: 10.1016/j.cell.2016.03.015. Cell. 2016. PMID: 27058663 Free PMC article.
Precision medicine needs pioneering clinical bioinformaticians.
Gómez-López G, Dopazo J, Cigudosa JC, Valencia A, Al-Shahrour F. Gómez-López G, et al. Brief Bioinform. 2019 May 21;20(3):752-766. doi: 10.1093/bib/bbx144. Brief Bioinform. 2019. PMID: 29077790 Free article. Review.
Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors.
Djurec M, Graña O, Lee A, Troulé K, Espinet E, Cabras L, Navas C, Blasco MT, Martín-Díaz L, Burdiel M, Li J, Liu Z, Vallespinós M, Sanchez-Bueno F, Sprick MR, Trumpp A, Sainz B Jr, Al-Shahrour F, Rabadan R, Guerra C, Barbacid M. Djurec M, et al. Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):E1147-E1156. doi: 10.1073/pnas.1717802115. Epub 2018 Jan 19. Proc Natl Acad Sci U S A. 2018. PMID: 29351990 Free PMC article.
In vivo phosphoproteomics reveals kinase activity profiles that predict treatment outcome in triple-negative breast cancer.
Zagorac I, Fernandez-Gaitero S, Penning R, Post H, Bueno MJ, Mouron S, Manso L, Morente MM, Alonso S, Serra V, Muñoz J, Gómez-López G, Lopez-Acosta JF, Jimenez-Renard V, Gris-Oliver A, Al-Shahrour F, Piñeiro-Yañez E, Montoya-Suarez JL, Apala JV, Moreno-Torres A, Colomer R, Dopazo A, Heck AJR, Altelaar M, Quintela-Fandino M. Zagorac I, et al. Nat Commun. 2018 Aug 29;9(1):3501. doi: 10.1038/s41467-018-05742-z. Nat Commun. 2018. PMID: 30158526 Free PMC article.
160 results