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Inhibition of pancreatic EZH2 restores progenitor insulin in T1D donor.
Al-Hasani K, Khurana I, Mariana L, Loudovaris T, Maxwell S, Harikrishnan KN, Okabe J, Cooper ME, El-Osta A. Al-Hasani K, et al. Signal Transduct Target Ther. 2022 Jul 22;7(1):248. doi: 10.1038/s41392-022-01034-7. Signal Transduct Target Ther. 2022. PMID: 35864094 Free PMC article.
Epigenetic evidence of an Ac/Dc axis by VPA and SAHA.
Lunke S, Maxwell S, Khurana I, K N H, Okabe J, Al-Hasani K, El-Osta A. Lunke S, et al. Clin Epigenetics. 2021 Mar 20;13(1):58. doi: 10.1186/s13148-021-01050-4. Clin Epigenetics. 2021. PMID: 33743782 Free PMC article.
SAHA attenuates Takotsubo-like myocardial injury by targeting an epigenetic Ac/Dc axis.
Khurana I, Maxwell S, Royce S, Mathiyalagan P, Karagiannis T, Mazarakis N, Vongsvivut J, K N H, Okabe J, Al-Hasani K, Samuel C, El-Osta A. Khurana I, et al. Among authors: al hasani k. Signal Transduct Target Ther. 2021 Apr 20;6(1):159. doi: 10.1038/s41392-021-00546-y. Signal Transduct Target Ther. 2021. PMID: 33875635 Free PMC article. No abstract available.
Microencapsulation-based cell therapies.
Marikar SN, El-Osta A, Johnston A, Such G, Al-Hasani K. Marikar SN, et al. Among authors: al hasani k. Cell Mol Life Sci. 2022 Jun 8;79(7):351. doi: 10.1007/s00018-022-04369-0. Cell Mol Life Sci. 2022. PMID: 35674842 Free PMC article. Review.
Epigenetic-mediated reprogramming of pancreatic endocrine cells.
Mathiyalagan P, Keating ST, Al-Hasani K, El-Osta A. Mathiyalagan P, et al. Antioxid Redox Signal. 2015 Jun 1;22(16):1483-95. doi: 10.1089/ars.2014.6103. Epub 2015 Mar 18. Antioxid Redox Signal. 2015. PMID: 25621632 Review.
Adult duct-lining cells can reprogram into β-like cells able to counter repeated cycles of toxin-induced diabetes.
Al-Hasani K, Pfeifer A, Courtney M, Ben-Othman N, Gjernes E, Vieira A, Druelle N, Avolio F, Ravassard P, Leuckx G, Lacas-Gervais S, Ambrosetti D, Benizri E, Hecksher-Sorensen J, Gounon P, Ferrer J, Gradwohl G, Heimberg H, Mansouri A, Collombat P. Al-Hasani K, et al. Dev Cell. 2013 Jul 15;26(1):86-100. doi: 10.1016/j.devcel.2013.05.018. Epub 2013 Jun 27. Dev Cell. 2013. PMID: 23810513 Free article.
Long-Term GABA Administration Induces Alpha Cell-Mediated Beta-like Cell Neogenesis.
Ben-Othman N, Vieira A, Courtney M, Record F, Gjernes E, Avolio F, Hadzic B, Druelle N, Napolitano T, Navarro-Sanz S, Silvano S, Al-Hasani K, Pfeifer A, Lacas-Gervais S, Leuckx G, Marroquí L, Thévenet J, Madsen OD, Eizirik DL, Heimberg H, Kerr-Conte J, Pattou F, Mansouri A, Collombat P. Ben-Othman N, et al. Cell. 2017 Jan 12;168(1-2):73-85.e11. doi: 10.1016/j.cell.2016.11.002. Epub 2016 Dec 1. Cell. 2017. PMID: 27916274 Free article.
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