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FTLD-TDP assemblies seed neoaggregates with subtype-specific features via a prion-like cascade.
De Rossi P, Lewis AJ, Furrer J, De Vos L, Demeter T, Zbinden A, Zhong W, Wiersma VI, Scialo C, Weber J, Guo Z, Scaramuzza S, Di Fabrizio M, Böing C, Castaño-Díez D, Al-Amoudi A, Pérez-Berlanga M, Lashley T, Stahlberg H, Polymenidou M. De Rossi P, et al. Among authors: al amoudi a. EMBO Rep. 2021 Dec 6;22(12):e53877. doi: 10.15252/embr.202153877. Epub 2021 Nov 22. EMBO Rep. 2021. PMID: 34806807 Free PMC article.
TDP-43 extracted from frontotemporal lobar degeneration subject brains displays distinct aggregate assemblies and neurotoxic effects reflecting disease progression rates.
Laferrière F, Maniecka Z, Pérez-Berlanga M, Hruska-Plochan M, Gilhespy L, Hock EM, Wagner U, Afroz T, Boersema PJ, Barmettler G, Foti SC, Asi YT, Isaacs AM, Al-Amoudi A, Lewis A, Stahlberg H, Ravits J, De Giorgi F, Ichas F, Bezard E, Picotti P, Lashley T, Polymenidou M. Laferrière F, et al. Nat Neurosci. 2019 Jan;22(1):65-77. doi: 10.1038/s41593-018-0294-y. Epub 2018 Dec 17. Nat Neurosci. 2019. PMID: 30559480
The three-dimensional molecular structure of the desmosomal plaque.
Al-Amoudi A, Castaño-Diez D, Devos DP, Russell RB, Johnson GT, Frangakis AS. Al-Amoudi A, et al. Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6480-5. doi: 10.1073/pnas.1019469108. Epub 2011 Apr 4. Proc Natl Acad Sci U S A. 2011. PMID: 21464301 Free PMC article.
Fiducial-less alignment of cryo-sections.
Castaño-Díez D, Al-Amoudi A, Glynn AM, Seybert A, Frangakis AS. Castaño-Díez D, et al. J Struct Biol. 2007 Sep;159(3):413-23. doi: 10.1016/j.jsb.2007.04.014. Epub 2007 Jun 9. J Struct Biol. 2007. PMID: 17651988
50 results