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PRL-3 activates mTORC1 in Cancer Progression.
Ye Z, Al-Aidaroos AQ, Park JE, Yuen HF, Zhang SD, Gupta A, Lin Y, Shen HM, Zeng Q. Ye Z, et al. Among authors: al aidaroos aq. Sci Rep. 2015 Nov 24;5:17046. doi: 10.1038/srep17046. Sci Rep. 2015. PMID: 26597054 Free PMC article.
PRL3-zumab, a first-in-class humanized antibody for cancer therapy.
Thura M, Al-Aidaroos AQO, Yong WP, Kono K, Gupta A, Lin YB, Mimura K, Thiery JP, Goh BC, Tan P, Soo R, Hong CW, Wang L, Lin SJ, Chen E, Rha SY, Chung HC, Li J, Nandi S, Yuen HF, Zhang SD, Guan YK, So J, Zeng Q. Thura M, et al. Among authors: al aidaroos aqo. JCI Insight. 2016 Jun 16;1(9):e87607. doi: 10.1172/jci.insight.87607. JCI Insight. 2016. PMID: 27699276 Free PMC article.
A Phase I, First-in-Human Study of PRL3-zumab in Advanced, Refractory Solid Tumors and Hematological Malignancies.
Chee CE, Ooi M, Lee SC, Sundar R, Heong V, Yong WP, Ng CH, Wong A, Lim JSJ, Tan DSP, Soo R, Tan JTC, Yang S, Thura M, Al-Aidaroos AQ, Chng WJ, Zeng Q, Goh BC. Chee CE, et al. Among authors: al aidaroos aq. Target Oncol. 2023 May;18(3):391-402. doi: 10.1007/s11523-023-00962-w. Epub 2023 Apr 15. Target Oncol. 2023. PMID: 37060431 Free PMC article. Clinical Trial.
Author Correction: PRL3-zumab as an immunotherapy to inhibit tumors expressing PRL3 oncoprotein.
Thura M, Al-Aidaroos AQ, Gupta A, Chee CE, Lee SC, Hui KM, Li J, Guan YK, Yong WP, So J, Chng WJ, Ng CH, Zhou J, Wang LZ, Yuen JSP, Ho HSS, Yi SM, Chiong E, Choo SP, Ngeow J, Ng MCH, Chua C, Yeo ESA, Tan IBH, Sng JXE, Tan NYZ, Thiery JP, Goh BC, Zeng Q. Thura M, et al. Among authors: al aidaroos aq. Nat Commun. 2021 Nov 2;12(1):6431. doi: 10.1038/s41467-021-26548-6. Nat Commun. 2021. PMID: 34728638 Free PMC article. No abstract available.
PRL3-zumab as an immunotherapy to inhibit tumors expressing PRL3 oncoprotein.
Thura M, Al-Aidaroos AQ, Gupta A, Chee CE, Lee SC, Hui KM, Li J, Guan YK, Yong WP, So J, Chng WJ, Ng CH, Zhou J, Wang LZ, Yuen JSP, Ho HSS, Yi SM, Chiong E, Choo SP, Ngeow J, Ng MCH, Chua C, Yeo ESA, Tan IBH, Sng JXE, Tan NYZ, Thiery JP, Goh BC, Zeng Q. Thura M, et al. Among authors: al aidaroos aq. Nat Commun. 2019 Jun 6;10(1):2484. doi: 10.1038/s41467-019-10127-x. Nat Commun. 2019. PMID: 31171773 Free PMC article.
Dual-faced SH3BGRL: oncogenic in mice, tumor suppressive in humans.
Wang H, Liu B, Al-Aidaroos AQ, Shi H, Li L, Guo K, Li J, Tan BC, Loo JM, Tang JP, Thura M, Zeng Q. Wang H, et al. Among authors: al aidaroos aq. Oncogene. 2016 Jun 23;35(25):3303-13. doi: 10.1038/onc.2015.391. Epub 2015 Oct 12. Oncogene. 2016. PMID: 26455318 Free PMC article.
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