Al-Abed Y - Search Results

1

ISO-66, a novel inhibitor of macrophage migration, shows efficacy in melanoma and colon cancer models.

Ioannou K, Cheng KF, Crichlow GV, Birmpilis AI, Lolis EJ, Tsitsilonis OE, Al-Abed Y. Ioannou K, et al. Int J Oncol. 2014 Oct;45(4):1457-68. doi: 10.3892/ijo.2014.2551. Epub 2014 Jul 22. Int J Oncol. 2014. PMID: 25050663 Free PMC article.

2

The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents.

Lubetsky JB, Dios A, Han J, Aljabari B, Ruzsicska B, Mitchell R, Lolis E, Al-Abed Y. Lubetsky JB, et al. J Biol Chem. 2002 Jul 12;277(28):24976-82. doi: 10.1074/jbc.M203220200. Epub 2002 May 7. J Biol Chem. 2002. PMID: 11997397 Free article.

3

Inhibition of MIF bioactivity by rational design of pharmacological inhibitors of MIF tautomerase activity.

Dios A, Mitchell RA, Aljabari B, Lubetsky J, O'Connor K, Liao H, Senter PD, Manogue KR, Lolis E, Metz C, Bucala R, Callaway DJ, Al-Abed Y. Dios A, et al. J Med Chem. 2002 Jun 6;45(12):2410-6. doi: 10.1021/jm010534q. J Med Chem. 2002. PMID: 12036350

4

Critical modifications of the ISO-1 scaffold improve its potent inhibition of macrophage migration inhibitory factor (MIF) tautomerase activity.

Cheng KF, Al-Abed Y. Cheng KF, et al. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3376-9. doi: 10.1016/j.bmcl.2006.04.038. Epub 2006 May 6. Bioorg Med Chem Lett. 2006. PMID: 16682188

5

Lung-derived macrophage migration inhibitory factor in sepsis induces cardio-circulatory depression.

Sakuragi T, Lin X, Metz CN, Ojamaa K, Kohn N, Al-Abed Y, Miller EJ. Sakuragi T, et al. Surg Infect (Larchmt). 2007 Feb;8(1):29-40. doi: 10.1089/sur.2006.031. Surg Infect (Larchmt). 2007. PMID: 17381395 Free PMC article.

6

Phenolic hydrazones are potent inhibitors of macrophage migration inhibitory factor proinflammatory activity and survival improving agents in sepsis.

Dabideen DR, Cheng KF, Aljabari B, Miller EJ, Pavlov VA, Al-Abed Y. Dabideen DR, et al. J Med Chem. 2007 Apr 19;50(8):1993-7. doi: 10.1021/jm061477+. Epub 2007 Mar 27. J Med Chem. 2007. PMID: 17385848 Free PMC article.

7

Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor.

Crichlow GV, Cheng KF, Dabideen D, Ochani M, Aljabari B, Pavlov VA, Miller EJ, Lolis E, Al-Abed Y. Crichlow GV, et al. J Biol Chem. 2007 Aug 10;282(32):23089-95. doi: 10.1074/jbc.M701825200. Epub 2007 May 25. J Biol Chem. 2007. PMID: 17526494 Free PMC article.

8

Novel nitric oxide-donating compound (S,R)-3-phenyl-4,5-dihydro-5-isoxazole acetic acid-nitric oxide (GIT-27NO) induces p53 mediated apoptosis in human A375 melanoma cells.

Mijatovic S, Maksimovic-Ivanic D, Mojic M, Malaponte G, Libra M, Cardile V, Miljkovic D, Harhaji L, Dabideen D, Cheng KF, Bevelacqua Y, Donia M, Garotta G, Al-Abed Y, Stosic-Grujicic S, Nicoletti F. Mijatovic S, et al. Nitric Oxide. 2008 Sep;19(2):177-83. doi: 10.1016/j.niox.2008.04.004. Epub 2008 May 19. Nitric Oxide. 2008. PMID: 18460348

9

The antitumor properties of a nontoxic, nitric oxide-modified version of saquinavir are independent of Akt.

Maksimovic-Ivanic D, Mijatovic S, Miljkovic D, Harhaji-Trajkovic L, Timotijevic G, Mojic M, Dabideen D, Cheng KF, McCubrey JA, Mangano K, Al-Abed Y, Libra M, Garotta G, Stosic-Grujicic S, Nicoletti F. Maksimovic-Ivanic D, et al. Mol Cancer Ther. 2009 May;8(5):1169-78. doi: 10.1158/1535-7163.MCT-08-0998. Epub 2009 May 5. Mol Cancer Ther. 2009. PMID: 19417156

10

ISO-1, a macrophage migration inhibitory factor antagonist, inhibits airway remodeling in a murine model of chronic asthma.

Chen PF, Luo YL, Wang W, Wang JX, Lai WY, Hu SM, Cheng KF, Al-Abed Y. Chen PF, et al. Mol Med. 2010 Sep-Oct;16(9-10):400-8. doi: 10.2119/molmed.2009.00128. Epub 2010 May 14. Mol Med. 2010. PMID: 20485865 Free PMC article.

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