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TW68, cryptochromes stabilizer, regulates fasting blood glucose levels in diabetic ob/ob and high fat-diet-induced obese mice.
Biochem Pharmacol. 2023 Dec;218:115896. doi: 10.1016/j.bcp.2023.115896. Epub 2023 Oct 28.
Biochem Pharmacol. 2023.
PMID: 37898388
A CLOCK-binding small molecule disrupts the interaction between CLOCK and BMAL1 and enhances circadian rhythm amplitude.
Doruk YU, Yarparvar D, Akyel YK, Gul S, Taskin AC, Yilmaz F, Baris I, Ozturk N, Türkay M, Ozturk N, Okyar A, Kavakli IH.
Doruk YU, et al. Among authors: akyel yk.
J Biol Chem. 2020 Mar 13;295(11):3518-3531. doi: 10.1074/jbc.RA119.011332. Epub 2020 Feb 4.
J Biol Chem. 2020.
PMID: 32019867
Free PMC article.
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Discovery of a small molecule that selectively destabilizes Cryptochrome 1 and enhances life span in p53 knockout mice.
Gul S, Akyel YK, Gul ZM, Isin S, Ozcan O, Korkmaz T, Selvi S, Danis I, Ipek OS, Aygenli F, Taskin AC, Akarlar BA, Ozlu N, Ozturk N, Ozturk N, Ünal DÖ, Guzel M, Turkay M, Okyar A, Kavakli IH.
Gul S, et al. Among authors: akyel yk.
Nat Commun. 2022 Nov 8;13(1):6742. doi: 10.1038/s41467-022-34582-1.
Nat Commun. 2022.
PMID: 36347873
Free PMC article.
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Diurnal Changes in Capecitabine Clock-Controlled Metabolism Enzymes Are Responsible for Its Pharmacokinetics in Male Mice.
Akyel YK, Ozturk Civelek D, Ozturk Seyhan N, Gul S, Gazioglu I, Pala Kara Z, Lévi F, Kavakli IH, Okyar A.
Akyel YK, et al.
J Biol Rhythms. 2023 Apr;38(2):171-184. doi: 10.1177/07487304221148779. Epub 2023 Feb 10.
J Biol Rhythms. 2023.
PMID: 36762608
Free PMC article.
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Circadian Dysfunction in Adipose Tissue: Chronotherapy in Metabolic Diseases.
Civelek E, Ozturk Civelek D, Akyel YK, Kaleli Durman D, Okyar A.
Civelek E, et al. Among authors: akyel yk.
Biology (Basel). 2023 Aug 2;12(8):1077. doi: 10.3390/biology12081077.
Biology (Basel). 2023.
PMID: 37626963
Free PMC article.
Review.
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Dosing-time, feeding, and sex-dependent variations of everolimus pharmacokinetics in mice.
Ozturk Civelek D, Ozturk Seyhan N, Akyel YK, Gazioglu I, Pala Kara Z, Orman MN, Okyar A.
Ozturk Civelek D, et al. Among authors: akyel yk.
Fundam Clin Pharmacol. 2024 Mar 18. doi: 10.1111/fcp.13003. Online ahead of print.
Fundam Clin Pharmacol. 2024.
PMID: 38500383
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