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Efficient synthesis and first regioselective C-6 direct arylation of imidazo[2,1-c][1,2,4]triazine scaffold and their evaluation in H2O2-induced oxidative stress.
Loubidi M, Jouha J, Tber Z, Khouili M, Suzenet F, Akssira M, Erdogan MA, Köse FA, Dagcı T, Armagan G, Saso L, Guillaumet G. Loubidi M, et al. Among authors: akssira m. Eur J Med Chem. 2018 Feb 10;145:113-123. doi: 10.1016/j.ejmech.2017.12.081. Epub 2017 Dec 27. Eur J Med Chem. 2018. PMID: 29324335
Advances in tetrahydropyrido[1,2-a]isoindolone (valmerins) series: Potent glycogen synthase kinase 3 and cyclin dependent kinase 5 inhibitors.
Boulahjar R, Ouach A, Bourg S, Bonnet P, Lozach O, Meijer L, Guguen-Guillouzo C, Le Guevel R, Lazar S, Akssira M, Troin Y, Guillaumet G, Routier S. Boulahjar R, et al. Among authors: akssira m. Eur J Med Chem. 2015 Aug 28;101:274-87. doi: 10.1016/j.ejmech.2015.06.046. Epub 2015 Jun 27. Eur J Med Chem. 2015. PMID: 26142492 Free article.
Novel tetrahydropyrido[1,2-a]isoindolone derivatives (valmerins): potent cyclin-dependent kinase/glycogen synthase kinase 3 inhibitors with antiproliferative activities and antitumor effects in human tumor xenografts.
Boulahjar R, Ouach A, Matteo C, Bourg S, Ravache M, le Guével R, Marionneau S, Oullier T, Lozach O, Meijer L, Guguen-Guillouzo C, Lazar S, Akssira M, Troin Y, Guillaumet G, Routier S. Boulahjar R, et al. Among authors: akssira m. J Med Chem. 2012 Nov 26;55(22):9589-606. doi: 10.1021/jm3008536. Epub 2012 Nov 1. J Med Chem. 2012. PMID: 23083119
Abietane diterpenes from the cones of Cedrus atlantica.
Barrero AF, Quílez del Moral JF, Mar Herrador M, Arteaga JF, Akssira M, Benharref A, Dakir M. Barrero AF, et al. Among authors: akssira m. Phytochemistry. 2005 Jan;66(1):105-11. doi: 10.1016/j.phytochem.2004.10.017. Phytochemistry. 2005. PMID: 15649517
Transtaganolides A-D: novel metabolites from Thapsia transtagana.
Saouf A, Guerra FM, Rubal JJ, Moreno-Dorado FJ, Akssira M, Mellouki F, López M, Pujadas AJ, Jorge ZD, Massanet GM. Saouf A, et al. Among authors: akssira m. Org Lett. 2005 Mar 3;7(5):881-4. doi: 10.1021/ol047421w. Org Lett. 2005. PMID: 15727465
Phenylpropanoids from Thapsia transtagana.
Saouf A, Guerra FM, Rubal JJ, Jorge ZD, Akssira M, Mellouki F, Moreno-Dorado FJ, Massanet GM. Saouf A, et al. Among authors: akssira m. Phytochemistry. 2006 Apr;67(8):800-4. doi: 10.1016/j.phytochem.2006.01.032. Epub 2006 Mar 15. Phytochemistry. 2006. PMID: 16540132
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