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aPKClambda/iota promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6.
Ishiguro H, Akimoto K, Nagashima Y, Kojima Y, Sasaki T, Ishiguro-Imagawa Y, Nakaigawa N, Ohno S, Kubota Y, Uemura H. Ishiguro H, et al. Among authors: akimoto k. Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16369-74. doi: 10.1073/pnas.0907044106. Epub 2009 Sep 2. Proc Natl Acad Sci U S A. 2009. PMID: 19805306 Free PMC article.
High expression of KIBRA in low atypical protein kinase C-expressing gastric cancer correlates with lymphatic invasion and poor prognosis.
Yoshihama Y, Izumisawa Y, Akimoto K, Satoh Y, Mizushima T, Satoh K, Chida K, Takagawa R, Akiyama H, Ichikawa Y, Kunisaki C, Inayama Y, Endo I, Nagashima Y, Ohno S. Yoshihama Y, et al. Among authors: akimoto k. Cancer Sci. 2013 Feb;104(2):259-65. doi: 10.1111/cas.12066. Epub 2012 Dec 27. Cancer Sci. 2013. PMID: 23163744 Free PMC article.
aPKCλ/ι is a beneficial prognostic marker for pancreatic neoplasms.
Kato S, Akimoto K, Nagashima Y, Ishiguro H, Kubota K, Kobayashi N, Hosono K, Watanabe S, Sekino Y, Sato T, Sasaki K, Nakaigawa N, Kubota Y, Inayama Y, Endo I, Ohno S, Maeda S, Nakajima A. Kato S, et al. Among authors: akimoto k. Pancreatology. 2013 Jul-Aug;13(4):360-8. doi: 10.1016/j.pan.2013.05.006. Epub 2013 May 22. Pancreatology. 2013. PMID: 23890134
Colorectal laterally spreading tumors show characteristic expression of cell polarity factors, including atypical protein kinase C λ/ι, E-cadherin, β-catenin and basement membrane component.
Ichikawa Y, Nagashima Y, Morioka K, Akimoto K, Kojima Y, Ishikawa T, Goto A, Kobayashi N, Watanabe K, Ota M, Fujii S, Kawamata M, Takagawa R, Kunizaki C, Takahashi H, Nakajima A, Maeda S, Shimada H, Inayama Y, Ohno S, Endo I. Ichikawa Y, et al. Among authors: akimoto k. Oncol Lett. 2014 Sep;8(3):977-984. doi: 10.3892/ol.2014.2271. Epub 2014 Jun 20. Oncol Lett. 2014. PMID: 25120645 Free PMC article.
Aberrant Expression of the Cell Polarity Regulator aPKCλ/ι is Associated With Disease Progression in Cervical Intraepithelial Neoplasia (CIN): A Possible Marker for Predicting CIN Prognosis.
Mizushima T, Asai-Sato M, Akimoto K, Nagashima Y, Taguri M, Sasaki K, Nakaya MA, Asano R, Tokinaga A, Kiyono T, Hirahara F, Ohno S, Miyagi E. Mizushima T, et al. Among authors: akimoto k. Int J Gynecol Pathol. 2016 Mar;35(2):106-17. doi: 10.1097/PGP.0000000000000228. Int J Gynecol Pathol. 2016. PMID: 26535980
488 results