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A Penicillium sp. F33 metabolite and its synthetic derivatives inhibit acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase (a key enzyme in platelet-activating factor biosynthesis) and carrageenan-induced paw edema in mice.
Yamazaki Y, Yasuda K, Matsuyama T, Ishihara T, Higa R, Sawairi T, Yamaguchi M, Egi M, Akai S, Miyase T, Ikari A, Miwa M, Sugatani J. Yamazaki Y, et al. Among authors: akai s. Biochem Pharmacol. 2013 Sep 1;86(5):632-44. doi: 10.1016/j.bcp.2013.06.021. Epub 2013 Jun 28. Biochem Pharmacol. 2013. PMID: 23817078
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