Akahata W - Search Results

1

A virus-like particle vaccine prevents equine encephalitis virus infection in nonhuman primates.

Ko SY, Akahata W, Yang ES, Kong WP, Burke CW, Honnold SP, Nichols DK, Huang YS, Schieber GL, Carlton K, DaSilva L, Traina-Dorge V, Vanlandingham DL, Tsybovsky Y, Stephens T, Baxa U, Higgs S, Roy CJ, Glass PJ, Mascola JR, Nabel GJ, Rao SS. Ko SY, et al. Among authors: akahata w. Sci Transl Med. 2019 May 15;11(492):eaav3113. doi: 10.1126/scitranslmed.aav3113. Sci Transl Med. 2019. PMID: 31092692

2

A virus-like particle vaccine for epidemic Chikungunya virus protects nonhuman primates against infection.

Akahata W, Yang ZY, Andersen H, Sun S, Holdaway HA, Kong WP, Lewis MG, Higgs S, Rossmann MG, Rao S, Nabel GJ. Akahata W, et al. Nat Med. 2010 Mar;16(3):334-8. doi: 10.1038/nm.2105. Epub 2010 Jan 28. Nat Med. 2010. PMID: 20111039 Free PMC article.

3

Comparative immunogenicity of human immunodeficiency virus particles and corresponding polypeptides in a DNA vaccine.

Akahata W, Yang ZY, Nabel GJ. Akahata W, et al. J Virol. 2005 Jan;79(1):626-31. doi: 10.1128/JVI.79.1.626-631.2005. J Virol. 2005. PMID: 15596858 Free PMC article.

4

A specific domain of the Chikungunya virus E2 protein regulates particle formation in human cells: implications for alphavirus vaccine design.

Akahata W, Nabel GJ. Akahata W, et al. J Virol. 2012 Aug;86(16):8879-83. doi: 10.1128/JVI.00370-12. Epub 2012 May 30. J Virol. 2012. PMID: 22647698 Free PMC article.

5

Safety and tolerability of chikungunya virus-like particle vaccine in healthy adults: a phase 1 dose-escalation trial.

Chang LJ, Dowd KA, Mendoza FH, Saunders JG, Sitar S, Plummer SH, Yamshchikov G, Sarwar UN, Hu Z, Enama ME, Bailer RT, Koup RA, Schwartz RM, Akahata W, Nabel GJ, Mascola JR, Pierson TC, Graham BS, Ledgerwood JE; VRC 311 Study Team. Chang LJ, et al. Among authors: akahata w. Lancet. 2014 Dec 6;384(9959):2046-52. doi: 10.1016/S0140-6736(14)61185-5. Epub 2014 Aug 14. Lancet. 2014. PMID: 25132507 Clinical Trial.

6

Different vaccine vectors delivering the same antigen elicit CD8+ T cell responses with distinct clonotype and epitope specificity.

Honda M, Wang R, Kong WP, Kanekiyo M, Akahata W, Xu L, Matsuo K, Natarajan K, Robinson H, Asher TE, Price DA, Douek DC, Margulies DH, Nabel GJ. Honda M, et al. Among authors: akahata w. J Immunol. 2009 Aug 15;183(4):2425-34. doi: 10.4049/jimmunol.0900581. Epub 2009 Jul 20. J Immunol. 2009. PMID: 19620307 Free PMC article.

7

Structural analyses at pseudo atomic resolution of Chikungunya virus and antibodies show mechanisms of neutralization.

Sun S, Xiang Y, Akahata W, Holdaway H, Pal P, Zhang X, Diamond MS, Nabel GJ, Rossmann MG. Sun S, et al. Among authors: akahata w. Elife. 2013 Apr 2;2:e00435. doi: 10.7554/eLife.00435. Elife. 2013. PMID: 23577234 Free PMC article.

8

Development of a highly protective combination monoclonal antibody therapy against Chikungunya virus.

Pal P, Dowd KA, Brien JD, Edeling MA, Gorlatov S, Johnson S, Lee I, Akahata W, Nabel GJ, Richter MK, Smit JM, Fremont DH, Pierson TC, Heise MT, Diamond MS. Pal P, et al. Among authors: akahata w. PLoS Pathog. 2013;9(4):e1003312. doi: 10.1371/journal.ppat.1003312. Epub 2013 Apr 18. PLoS Pathog. 2013. PMID: 23637602 Free PMC article.

9

Protein methyltransferase 2 inhibits NF-kappaB function and promotes apoptosis.

Ganesh L, Yoshimoto T, Moorthy NC, Akahata W, Boehm M, Nabel EG, Nabel GJ. Ganesh L, et al. Among authors: akahata w. Mol Cell Biol. 2006 May;26(10):3864-74. doi: 10.1128/MCB.26.10.3864-3874.2006. Mol Cell Biol. 2006. PMID: 16648481 Free PMC article.

10

Development of a Novel Virus-Like Particle Vaccine Platform That Mimics the Immature Form of Alphavirus.

Urakami A, Sakurai A, Ishikawa M, Yap ML, Flores-Garcia Y, Haseda Y, Aoshi T, Zavala FP, Rossmann MG, Kuno S, Ueno R, Akahata W. Urakami A, et al. Among authors: akahata w. Clin Vaccine Immunol. 2017 Jul 5;24(7):e00090-17. doi: 10.1128/CVI.00090-17. Print 2017 Jul. Clin Vaccine Immunol. 2017. PMID: 28515133 Free PMC article.

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