Ajito K - Search Results

1

Cross-Talk between Transforming Growth Factor-β and Periostin Can Be Targeted for Pulmonary Fibrosis.

Nanri Y, Nunomura S, Terasaki Y, Yoshihara T, Hirano Y, Yokosaki Y, Yamaguchi Y, Feghali-Bostwick C, Ajito K, Murakami S, Conway SJ, Izuhara K. Nanri Y, et al. Among authors: ajito k. Am J Respir Cell Mol Biol. 2020 Feb;62(2):204-216. doi: 10.1165/rcmb.2019-0245OC. Am J Respir Cell Mol Biol. 2020. PMID: 31505128 Free PMC article.

2

Periostin plays a critical role in the cell cycle in lung fibroblasts.

Yoshihara T, Nanri Y, Nunomura S, Yamaguchi Y, Feghali-Bostwick C, Ajito K, Murakami S, Mawatari M, Izuhara K. Yoshihara T, et al. Among authors: ajito k. Respir Res. 2020 Jan 30;21(1):38. doi: 10.1186/s12931-020-1299-0. Respir Res. 2020. PMID: 32000779 Free PMC article.

3

Tricyclic pharmacophore-based molecules as novel integrin alpha(v)beta3 antagonists. Part 1: design and synthesis of a lead compound exhibiting alpha(v)beta3/alpha(IIb)beta3 dual antagonistic activity.

Kubota D, Ishikawa M, Yamamoto M, Murakami S, Hachisu M, Katano K, Ajito K. Kubota D, et al. Among authors: ajito k. Bioorg Med Chem. 2006 Apr 1;14(7):2089-108. doi: 10.1016/j.bmc.2005.10.060. Epub 2005 Nov 23. Bioorg Med Chem. 2006. PMID: 16309911

4

Tricyclic pharmacophore-based molecules as novel integrin alpha(v)beta3 antagonists. Part 2: synthesis of potent alpha(v)beta3/alpha(IIb)beta3 dual antagonists.

Ishikawa M, Kubota D, Yamamoto M, Kuroda C, Iguchi M, Koyanagi A, Murakami S, Ajito K. Ishikawa M, et al. Among authors: ajito k. Bioorg Med Chem. 2006 Apr 1;14(7):2109-30. doi: 10.1016/j.bmc.2005.10.061. Epub 2005 Nov 23. Bioorg Med Chem. 2006. PMID: 16309912

5

Tricyclic pharmacophore-based molecules as novel integrin alphavbeta3 antagonists. Part IV: preliminary control of alphavbeta3 selectivity by meta-oriented substitution.

Kubota D, Ishikawa M, Ishikawa M, Yahata N, Murakami S, Fujishima K, Kitakaze M, Ajito K. Kubota D, et al. Among authors: ajito k. Bioorg Med Chem. 2006 Jun 15;14(12):4158-81. doi: 10.1016/j.bmc.2006.01.062. Epub 2006 Feb 28. Bioorg Med Chem. 2006. PMID: 16504518

6

Tricyclic pharmacophore-based molecules as novel integrin alpha(v)beta3 antagonists. Part III: synthesis of potent antagonists with alpha(v)beta3/alpha(IIb)beta3 dual activity and improved water solubility.

Ishikawa M, Hiraiwa Y, Kubota D, Tsushima M, Watanabe T, Murakami S, Ouchi S, Ajito K. Ishikawa M, et al. Among authors: ajito k. Bioorg Med Chem. 2006 Apr 1;14(7):2131-50. doi: 10.1016/j.bmc.2005.10.055. Epub 2005 Nov 22. Bioorg Med Chem. 2006. PMID: 16307881

7

A proof of the specificity of kanamycin-ribosomal RNA interaction with designed synthetic analogs and the antibacterial activity.

Nishimura Y, Adachi H, Kyo M, Murakami S, Hattori S, Ajito K. Nishimura Y, et al. Among authors: ajito k. Bioorg Med Chem Lett. 2005 Apr 15;15(8):2159-62. doi: 10.1016/j.bmcl.2005.02.043. Bioorg Med Chem Lett. 2005. PMID: 15808488

8

Synthesis and structure-activity relationships of novel lincomycin derivatives part 3: discovery of the 4-(pyrimidin-5-yl)phenyl group in synthesis of 7(S)-thiolincomycin analogs.

Wakiyama Y, Kumura K, Umemura E, Masaki S, Ueda K, Sato Y, Watanabe T, Hirai Y, Ajito K. Wakiyama Y, et al. Among authors: ajito k. J Antibiot (Tokyo). 2017 Jan;70(1):52-64. doi: 10.1038/ja.2016.114. Epub 2016 Oct 5. J Antibiot (Tokyo). 2017. PMID: 27703159

9

Synthesis and SARs of novel lincomycin derivatives Part 5: optimization of lincomycin analogs exhibiting potent antibacterial activities by chemical modification at the 6- and 7-positions.

Wakiyama Y, Kumura K, Umemura E, Masaki S, Ueda K, Sato Y, Hirai Y, Hayashi Y, Ajito K. Wakiyama Y, et al. Among authors: ajito k. J Antibiot (Tokyo). 2018 Feb;71(2):298-317. doi: 10.1038/ja.2017.114. Epub 2017 Nov 1. J Antibiot (Tokyo). 2018. PMID: 29089594

10

Synthesis and structure-activity relationships of novel lincomycin derivatives. Part 4: synthesis of novel lincomycin analogs modified at the 6- and 7-positions and their potent antibacterial activities.

Wakiyama Y, Kumura K, Umemura E, Ueda K, Watanabe T, Yamada K, Okutomi T, Ajito K. Wakiyama Y, et al. Among authors: ajito k. J Antibiot (Tokyo). 2017 Jul;70(8):888-906. doi: 10.1038/ja.2017.54. Epub 2017 May 31. J Antibiot (Tokyo). 2017. PMID: 28559581

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