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Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy.
Haikala HM, Anttila JM, Marques E, Raatikainen T, Ilander M, Hakanen H, Ala-Hongisto H, Savelius M, Balboa D, Von Eyss B, Eskelinen V, Munne P, Nieminen AI, Otonkoski T, Schüler J, Laajala TD, Aittokallio T, Sihto H, Mattson J, Heikkilä P, Leidenius M, Joensuu H, Mustjoki S, Kovanen P, Eilers M, Leverson JD, Klefström J. Haikala HM, et al. Among authors: aittokallio t. Nat Commun. 2019 Feb 6;10(1):620. doi: 10.1038/s41467-019-08541-2. Nat Commun. 2019. PMID: 30728358 Free PMC article.
Chk1 targeting reactivates PP2A tumor suppressor activity in cancer cells.
Khanna A, Kauko O, Böckelman C, Laine A, Schreck I, Partanen JI, Szwajda A, Bormann S, Bilgen T, Helenius M, Pokharel YR, Pimanda J, Russel MR, Haglund C, Cole KA, Klefström J, Aittokallio T, Weiss C, Ristimäki A, Visakorpi T, Westermarck J. Khanna A, et al. Among authors: aittokallio t. Cancer Res. 2013 Nov 15;73(22):6757-69. doi: 10.1158/0008-5472.CAN-13-1002. Epub 2013 Sep 26. Cancer Res. 2013. PMID: 24072747 Free PMC article.
Castration induces up-regulation of intratumoral androgen biosynthesis and androgen receptor expression in an orthotopic VCaP human prostate cancer xenograft model.
Knuuttila M, Yatkin E, Kallio J, Savolainen S, Laajala TD, Aittokallio T, Oksala R, Häkkinen M, Keski-Rahkonen P, Auriola S, Poutanen M, Mäkelä S. Knuuttila M, et al. Among authors: aittokallio t. Am J Pathol. 2014 Aug;184(8):2163-73. doi: 10.1016/j.ajpath.2014.04.010. Epub 2014 Jun 17. Am J Pathol. 2014. PMID: 24949550 Free article.
Optimized design and analysis of preclinical intervention studies in vivo.
Laajala TD, Jumppanen M, Huhtaniemi R, Fey V, Kaur A, Knuuttila M, Aho E, Oksala R, Westermarck J, Mäkelä S, Poutanen M, Aittokallio T. Laajala TD, et al. Among authors: aittokallio t. Sci Rep. 2016 Aug 2;6:30723. doi: 10.1038/srep30723. Sci Rep. 2016. PMID: 27480578 Free PMC article.
253 results