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Synthetic development of a broadly neutralizing antibody against snake venom long-chain α-neurotoxins.
Khalek IS, Senji Laxme RR, Nguyen YTK, Khochare S, Patel RN, Woehl J, Smith JM, Saye-Francisco K, Kim Y, Misson Mindrebo L, Tran Q, Kędzior M, Boré E, Limbo O, Verma M, Stanfield RL, Menzies SK, Ainsworth S, Harrison RA, Burton DR, Sok D, Wilson IA, Casewell NR, Sunagar K, Jardine JG. Khalek IS, et al. Among authors: ainsworth s. Sci Transl Med. 2024 Feb 21;16(735):eadk1867. doi: 10.1126/scitranslmed.adk1867. Epub 2024 Feb 21. Sci Transl Med. 2024. PMID: 38381847
The medical threat of mamba envenoming in sub-Saharan Africa revealed by genus-wide analysis of venom composition, toxicity and antivenomics profiling of available antivenoms.
Ainsworth S, Petras D, Engmark M, Süssmuth RD, Whiteley G, Albulescu LO, Kazandjian TD, Wagstaff SC, Rowley P, Wüster W, Dorrestein PC, Arias AS, Gutiérrez JM, Harrison RA, Casewell NR, Calvete JJ. Ainsworth S, et al. J Proteomics. 2018 Feb 10;172:173-189. doi: 10.1016/j.jprot.2017.08.016. Epub 2017 Aug 24. J Proteomics. 2018. PMID: 28843532 Free article.
Preclinical antivenom-efficacy testing reveals potentially disturbing deficiencies of snakebite treatment capability in East Africa.
Harrison RA, Oluoch GO, Ainsworth S, Alsolaiss J, Bolton F, Arias AS, Gutiérrez JM, Rowley P, Kalya S, Ozwara H, Casewell NR. Harrison RA, et al. Among authors: ainsworth s. PLoS Negl Trop Dis. 2017 Oct 18;11(10):e0005969. doi: 10.1371/journal.pntd.0005969. eCollection 2017 Oct. PLoS Negl Trop Dis. 2017. PMID: 29045429 Free PMC article.
The paraspecific neutralisation of snake venom induced coagulopathy by antivenoms.
Ainsworth S, Slagboom J, Alomran N, Pla D, Alhamdi Y, King SI, Bolton FMS, Gutiérrez JM, Vonk FJ, Toh CH, Calvete JJ, Kool J, Harrison RA, Casewell NR. Ainsworth S, et al. Commun Biol. 2018 Apr 19;1:34. doi: 10.1038/s42003-018-0039-1. eCollection 2018. Commun Biol. 2018. PMID: 30271920 Free PMC article.
Strategy for a globally coordinated response to a priority neglected tropical disease: Snakebite envenoming.
Williams DJ, Faiz MA, Abela-Ridder B, Ainsworth S, Bulfone TC, Nickerson AD, Habib AG, Junghanss T, Fan HW, Turner M, Harrison RA, Warrell DA. Williams DJ, et al. Among authors: ainsworth s. PLoS Negl Trop Dis. 2019 Feb 21;13(2):e0007059. doi: 10.1371/journal.pntd.0007059. eCollection 2019 Feb. PLoS Negl Trop Dis. 2019. PMID: 30789906 Free PMC article. No abstract available.
A Decoy-Receptor Approach Using Nicotinic Acetylcholine Receptor Mimics Reveals Their Potential as Novel Therapeutics Against Neurotoxic Snakebite.
Albulescu LO, Kazandjian T, Slagboom J, Bruyneel B, Ainsworth S, Alsolaiss J, Wagstaff SC, Whiteley G, Harrison RA, Ulens C, Kool J, Casewell NR. Albulescu LO, et al. Among authors: ainsworth s. Front Pharmacol. 2019 Jul 30;10:848. doi: 10.3389/fphar.2019.00848. eCollection 2019. Front Pharmacol. 2019. PMID: 31417406 Free PMC article.
Snake Venom Gland Organoids.
Post Y, Puschhof J, Beumer J, Kerkkamp HM, de Bakker MAG, Slagboom J, de Barbanson B, Wevers NR, Spijkers XM, Olivier T, Kazandjian TD, Ainsworth S, Iglesias CL, van de Wetering WJ, Heinz MC, van Ineveld RL, van Kleef RGDM, Begthel H, Korving J, Bar-Ephraim YE, Getreuer W, Rios AC, Westerink RHS, Snippert HJG, van Oudenaarden A, Peters PJ, Vonk FJ, Kool J, Richardson MK, Casewell NR, Clevers H. Post Y, et al. Among authors: ainsworth s. Cell. 2020 Jan 23;180(2):233-247.e21. doi: 10.1016/j.cell.2019.11.038. Cell. 2020. PMID: 31978343 Free article.
282 results