Aichem A - Search Results

1

FAT10 is phosphorylated by IKKβ to inhibit the antiviral type-I interferon response.

Saxena K, Roverato ND, Reithmann M, Mah MM, Schregle R, Schmidtke G, Silbern I, Urlaub H, Aichem A. Saxena K, et al. Among authors: aichem a. Life Sci Alliance. 2023 Nov 8;7(1):e202101282. doi: 10.26508/lsa.202101282. Print 2024 Jan. Life Sci Alliance. 2023. PMID: 37940187 Free PMC article.

2

FAT10 and NUB1L cooperate to activate the 26S proteasome.

Brockmann F, Catone N, Wünsch C, Offensperger F, Scheffner M, Schmidtke G, Aichem A. Brockmann F, et al. Among authors: aichem a. Life Sci Alliance. 2023 May 15;6(8):e202201463. doi: 10.26508/lsa.202201463. Print 2023 Aug. Life Sci Alliance. 2023. PMID: 37188463 Free PMC article.

3

The expression profile of the ubiquitin-like modifier FAT10 in immune cells suggests cell type-specific functions.

Schregle R, Mah MM, Mueller S, Aichem A, Basler M, Groettrup M. Schregle R, et al. Among authors: aichem a. Immunogenetics. 2018 Jul;70(7):429-438. doi: 10.1007/s00251-018-1055-5. Epub 2018 Mar 5. Immunogenetics. 2018. PMID: 29508036

4

FAT10 and NUB1L bind to the VWA domain of Rpn10 and Rpn1 to enable proteasome-mediated proteolysis.

Rani N, Aichem A, Schmidtke G, Kreft SG, Groettrup M. Rani N, et al. Among authors: aichem a. Nat Commun. 2012 Mar 20;3:749. doi: 10.1038/ncomms1752. Nat Commun. 2012. PMID: 22434192 Free article.

5

FAT10ylation as a signal for proteasomal degradation.

Schmidtke G, Aichem A, Groettrup M. Schmidtke G, et al. Among authors: aichem a. Biochim Biophys Acta. 2014 Jan;1843(1):97-102. doi: 10.1016/j.bbamcr.2013.01.009. Epub 2013 Jan 18. Biochim Biophys Acta. 2014. PMID: 23333871 Free article. Review.

6

Analysis of modification and proteolytic targeting by the ubiquitin-like modifier FAT10.

Aichem A, Boehm AN, Catone N, Schmidtke G, Groettrup M. Aichem A, et al. Methods Enzymol. 2019;618:229-256. doi: 10.1016/bs.mie.2018.12.040. Epub 2019 Feb 8. Methods Enzymol. 2019. PMID: 30850054

7

Parkin is an E3 ligase for the ubiquitin-like modifier FAT10, which inhibits Parkin activation and mitophagy.

Roverato ND, Sailer C, Catone N, Aichem A, Stengel F, Groettrup M. Roverato ND, et al. Among authors: aichem a. Cell Rep. 2021 Mar 16;34(11):108857. doi: 10.1016/j.celrep.2021.108857. Cell Rep. 2021. PMID: 33730565 Free article.

8

USE1 is a bispecific conjugating enzyme for ubiquitin and FAT10, which FAT10ylates itself in cis.

Aichem A, Pelzer C, Lukasiak S, Kalveram B, Sheppard PW, Rani N, Schmidtke G, Groettrup M. Aichem A, et al. Nat Commun. 2010 May 4;1:13. doi: 10.1038/ncomms1012. Nat Commun. 2010. PMID: 20975683 Free article.

9

The ubiquitin-like modifier FAT10 interferes with SUMO activation.

Aichem A, Sailer C, Ryu S, Catone N, Stankovic-Valentin N, Schmidtke G, Melchior F, Stengel F, Groettrup M. Aichem A, et al. Nat Commun. 2019 Oct 1;10(1):4452. doi: 10.1038/s41467-019-12430-z. Nat Commun. 2019. PMID: 31575873 Free PMC article.

10

The structure of the ubiquitin-like modifier FAT10 reveals an alternative targeting mechanism for proteasomal degradation.

Aichem A, Anders S, Catone N, Rößler P, Stotz S, Berg A, Schwab R, Scheuermann S, Bialas J, Schütz-Stoffregen MC, Schmidtke G, Peter C, Groettrup M, Wiesner S. Aichem A, et al. Nat Commun. 2018 Aug 20;9(1):3321. doi: 10.1038/s41467-018-05776-3. Nat Commun. 2018. PMID: 30127417 Free PMC article.

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