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Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity.
Cell Rep. 2019 Mar 12;26(11):2916-2928.e13. doi: 10.1016/j.celrep.2019.02.047.
Cell Rep. 2019.
PMID: 30865883
Free PMC article.
Targeting WDR5: A WINning Anti-Cancer Strategy?
Aho ER, Weissmiller AM, Fesik SW, Tansey WP.
Aho ER, et al.
Epigenet Insights. 2019 Jul 18;12:2516865719865282. doi: 10.1177/2516865719865282. eCollection 2019.
Epigenet Insights. 2019.
PMID: 31360909
Free PMC article.
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Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction.
Macdonald JD, Chacón Simon S, Han C, Wang F, Shaw JG, Howes JE, Sai J, Yuh JP, Camper D, Alicie BM, Alvarado J, Nikhar S, Payne W, Aho ER, Bauer JA, Zhao B, Phan J, Thomas LR, Rossanese OW, Tansey WP, Waterson AG, Stauffer SR, Fesik SW.
Macdonald JD, et al. Among authors: aho er.
J Med Chem. 2019 Dec 26;62(24):11232-11259. doi: 10.1021/acs.jmedchem.9b01411. Epub 2019 Dec 5.
J Med Chem. 2019.
PMID: 31724864
Free PMC article.
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WDR5 is a conserved regulator of protein synthesis gene expression.
Bryan AF, Wang J, Howard GC, Guarnaccia AD, Woodley CM, Aho ER, Rellinger EJ, Matlock BK, Flaherty DK, Lorey SL, Chung DH, Fesik SW, Liu Q, Weissmiller AM, Tansey WP.
Bryan AF, et al. Among authors: aho er.
Nucleic Acids Res. 2020 Apr 6;48(6):2924-2941. doi: 10.1093/nar/gkaa051.
Nucleic Acids Res. 2020.
PMID: 31996893
Free PMC article.
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Discovery and Structure-Based Optimization of Potent and Selective WD Repeat Domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core.
Tian J, Teuscher KB, Aho ER, Alvarado JR, Mills JJ, Meyers KM, Gogliotti RD, Han C, Macdonald JD, Sai J, Shaw JG, Sensintaffar JL, Zhao B, Rietz TA, Thomas LR, Payne WG, Moore WJ, Stott GM, Kondo J, Inoue M, Coffey RJ, Tansey WP, Stauffer SR, Lee T, Fesik SW.
Tian J, et al. Among authors: aho er.
J Med Chem. 2020 Jan 23;63(2):656-675. doi: 10.1021/acs.jmedchem.9b01608. Epub 2020 Jan 7.
J Med Chem. 2020.
PMID: 31858797
Free PMC article.
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A novel role for the mono-ADP-ribosyltransferase PARP14/ARTD8 in promoting homologous recombination and protecting against replication stress.
Nicolae CM, Aho ER, Choe KN, Constantin D, Hu HJ, Lee D, Myung K, Moldovan GL.
Nicolae CM, et al. Among authors: aho er.
Nucleic Acids Res. 2015 Mar 31;43(6):3143-53. doi: 10.1093/nar/gkv147. Epub 2015 Mar 9.
Nucleic Acids Res. 2015.
PMID: 25753673
Free PMC article.
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The ADP-ribosyltransferase PARP10/ARTD10 interacts with proliferating cell nuclear antigen (PCNA) and is required for DNA damage tolerance.
Nicolae CM, Aho ER, Vlahos AH, Choe KN, De S, Karras GI, Moldovan GL.
Nicolae CM, et al. Among authors: aho er.
J Biol Chem. 2014 May 9;289(19):13627-37. doi: 10.1074/jbc.M114.556340. Epub 2014 Apr 2.
J Biol Chem. 2014.
PMID: 24695737
Free PMC article.
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