Ahmed HEA - Search Results

1

N- and s-substituted Pyrazolopyrimidines: A promising new class of potent c-Src kinase inhibitors with prominent antitumor activity.

Awaji AA, Zaloa WAZE, Seleem MA, Alswah M, Elsebaei MM, Bayoumi AH, El-Morsy AM, Alfaifi MY, Shati AA, Elbehairi SEI, Almaghrabi M, Aljohani AKB, Ahmed HEA. Awaji AA, et al. Among authors: ahmed hea. Bioorg Chem. 2024 Apr;145:107228. doi: 10.1016/j.bioorg.2024.107228. Epub 2024 Feb 21. Bioorg Chem. 2024. PMID: 38422592

2

Antimicrobial screening and pharmacokinetic profiling of novel phenyl-[1,2,4]triazolo[4,3-a]quinoxaline analogues targeting DHFR and E. coli DNA gyrase B.

Omar AM, Alswah M, Ahmed HEA, Bayoumi AH, El-Gamal KM, El-Morsy A, Ghiaty A, Afifi TH, Sherbiny FF, Mohammed AS, Mansour BA. Omar AM, et al. Among authors: ahmed hea. Bioorg Chem. 2020 Mar;96:103656. doi: 10.1016/j.bioorg.2020.103656. Epub 2020 Feb 10. Bioorg Chem. 2020. PMID: 32062449

3

Design, Synthesis and Cytotoxic Evaluation of Novel Chalcone Derivatives Bearing Triazolo[4,3-a]-quinoxaline Moieties as Potent Anticancer Agents with Dual EGFR Kinase and Tubulin Polymerization Inhibitory Effects.

Alswah M, Bayoumi AH, Elgamal K, Elmorsy A, Ihmaid S, Ahmed HEA. Alswah M, et al. Among authors: ahmed hea. Molecules. 2017 Dec 27;23(1):48. doi: 10.3390/molecules23010048. Molecules. 2017. PMID: 29280968 Free PMC article.

4

Novel triazolophthalazine-hydrazone hybrids as potential PCAF inhibitors: Design, synthesis, in vitro anticancer evaluation, apoptosis, and molecular docking studies.

Abulkhair HS, Turky A, Ghiaty A, Ahmed HEA, Bayoumi AH. Abulkhair HS, et al. Among authors: ahmed hea. Bioorg Chem. 2020 Jul;100:103899. doi: 10.1016/j.bioorg.2020.103899. Epub 2020 May 17. Bioorg Chem. 2020. PMID: 32454390

5

Introducing of novel class of pyrano[2,3-c]pyrazole-5-carbonitrile analogs with potent antimicrobial activity, DNA gyrase inhibition, and prominent pharmacokinetic and CNS toxicity profiles supported by molecular dynamic simulation.

Almaghrabi M, Musa A, Aljohani AKB, Ahmed HEA, Alsulaimany M, Miski SF, Mostafa EM, Hussein S, Parambi DGT, Ghoneim MM, Elgammal WE, Halawa AH, Hammad A, El-Agrody AM. Almaghrabi M, et al. Among authors: ahmed hea. J Biomol Struct Dyn. 2023 Sep 3:1-18. doi: 10.1080/07391102.2023.2252088. Online ahead of print. J Biomol Struct Dyn. 2023. PMID: 37661733

6

Development of Novel Class of Phenylpyrazolo[3,4-d]pyrimidine-Based Analogs with Potent Anticancer Activity and Multitarget Enzyme Inhibition Supported by Docking Studies.

Aljohani AKB, El Zaloa WAZ, Alswah M, Seleem MA, Elsebaei MM, Bayoumi AH, El-Morsy AM, Almaghrabi M, Awaji AA, Hammad A, Alsulaimany M, Ahmed HEA. Aljohani AKB, et al. Among authors: ahmed hea. Int J Mol Sci. 2023 Oct 9;24(19):15026. doi: 10.3390/ijms241915026. Int J Mol Sci. 2023. PMID: 37834474 Free PMC article.

7

Novel 1,2,4-triazole derivatives: Design, synthesis, anticancer evaluation, molecular docking, and pharmacokinetic profiling studies.

Turky A, Sherbiny FF, Bayoumi AH, Ahmed HEA, Abulkhair HS. Turky A, et al. Among authors: ahmed hea. Arch Pharm (Weinheim). 2020 Dec;353(12):e2000170. doi: 10.1002/ardp.202000170. Epub 2020 Sep 6. Arch Pharm (Weinheim). 2020. PMID: 32893368

8

Novel molecular discovery of promising amidine-based thiazole analogues as potent dual Matrix Metalloproteinase-2 and 9 inhibitors: Anticancer activity data with prominent cell cycle arrest and DNA fragmentation analysis effects.

Omar AM, Bajorath J, Ihmaid S, Mohamed HM, El-Agrody AM, Mora A, El-Araby ME, Ahmed HEA. Omar AM, et al. Among authors: ahmed hea. Bioorg Chem. 2020 Aug;101:103992. doi: 10.1016/j.bioorg.2020.103992. Epub 2020 Jun 2. Bioorg Chem. 2020. PMID: 32554279

9

Synthesis, antimicrobial evaluation, DNA gyrase inhibition, and in silico pharmacokinetic studies of novel quinoline derivatives.

El-Shershaby MH, El-Gamal KM, Bayoumi AH, El-Adl K, Ahmed HEA, Abulkhair HS. El-Shershaby MH, et al. Among authors: ahmed hea. Arch Pharm (Weinheim). 2021 Feb;354(2):e2000277. doi: 10.1002/ardp.202000277. Epub 2020 Oct 20. Arch Pharm (Weinheim). 2021. PMID: 33078877

10

In vivo- and in silico-driven identification of novel synthetic quinoxalines as anticonvulsants and AMPA inhibitors.

Abulkhair HS, Elmeligie S, Ghiaty A, El-Morsy A, Bayoumi AH, Ahmed HEA, El-Adl K, Zayed MF, Hassan MH, Akl EN, El-Zoghbi MS. Abulkhair HS, et al. Among authors: ahmed hea. Arch Pharm (Weinheim). 2021 May;354(5):e2000449. doi: 10.1002/ardp.202000449. Epub 2021 Feb 9. Arch Pharm (Weinheim). 2021. PMID: 33559320

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