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PARP14 is a PARP with both ADP-ribosyl transferase and hydrolase activities.
Đukić N, Strømland Ø, Elsborg JD, Munnur D, Zhu K, Schuller M, Chatrin C, Kar P, Duma L, Suyari O, Rack JGM, Baretić D, Crudgington DRK, Groslambert J, Fowler G, Wijngaarden S, Prokhorova E, Rehwinkel J, Schüler H, Filippov DV, Sanyal S, Ahel D, Nielsen ML, Smith R, Ahel I. Đukić N, et al. Among authors: ahel d. Sci Adv. 2023 Sep 15;9(37):eadi2687. doi: 10.1126/sciadv.adi2687. Epub 2023 Sep 13. Sci Adv. 2023. PMID: 37703374 Free PMC article.
HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation.
Suskiewicz MJ, Zobel F, Ogden TEH, Fontana P, Ariza A, Yang JC, Zhu K, Bracken L, Hawthorne WJ, Ahel D, Neuhaus D, Ahel I. Suskiewicz MJ, et al. Among authors: ahel i, ahel d. Nature. 2020 Mar;579(7800):598-602. doi: 10.1038/s41586-020-2013-6. Epub 2020 Feb 6. Nature. 2020. PMID: 32028527 Free PMC article.
Serine-linked PARP1 auto-modification controls PARP inhibitor response.
Prokhorova E, Zobel F, Smith R, Zentout S, Gibbs-Seymour I, Schützenhofer K, Peters A, Groslambert J, Zorzini V, Agnew T, Brognard J, Nielsen ML, Ahel D, Huet S, Suskiewicz MJ, Ahel I. Prokhorova E, et al. Among authors: ahel d. Nat Commun. 2021 Jul 1;12(1):4055. doi: 10.1038/s41467-021-24361-9. Nat Commun. 2021. PMID: 34210965 Free PMC article.
Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease.
Prokhorova E, Agnew T, Wondisford AR, Tellier M, Kaminski N, Beijer D, Holder J, Groslambert J, Suskiewicz MJ, Zhu K, Reber JM, Krassnig SC, Palazzo L, Murphy S, Nielsen ML, Mangerich A, Ahel D, Baets J, O'Sullivan RJ, Ahel I. Prokhorova E, et al. Among authors: ahel d. Mol Cell. 2021 Jun 17;81(12):2640-2655.e8. doi: 10.1016/j.molcel.2021.04.028. Epub 2021 May 20. Mol Cell. 2021. PMID: 34019811 Free PMC article.
Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal.
Rack JGM, Liu Q, Zorzini V, Voorneveld J, Ariza A, Honarmand Ebrahimi K, Reber JM, Krassnig SC, Ahel D, van der Marel GA, Mangerich A, McCullagh JSO, Filippov DV, Ahel I. Rack JGM, et al. Among authors: ahel d. Nat Commun. 2021 Jul 28;12(1):4581. doi: 10.1038/s41467-021-24723-3. Nat Commun. 2021. PMID: 34321462 Free PMC article.
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