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3-H-[1,2]Dithiole as a New Anti-Trypanosoma cruzi Chemotype: Biological and Mechanism of Action Studies.
Couto M, Sánchez C, Dávila B, Machín V, Varela J, Álvarez G, Cabrera M, Celano L, Aguirre-López B, Cabrera N, de Gómez-Puyou MT, Gómez-Puyou A, Pérez-Montfort R, Cerecetto H, González M. Couto M, et al. Among authors: aguirre lopez b. Molecules. 2015 Aug 12;20(8):14595-610. doi: 10.3390/molecules200814595. Molecules. 2015. PMID: 26274947 Free PMC article.
Massive screening yields novel and selective Trypanosoma cruzi triosephosphate isomerase dimer-interface-irreversible inhibitors with anti-trypanosomal activity.
Alvarez G, Aguirre-López B, Varela J, Cabrera M, Merlino A, López GV, Lavaggi ML, Porcal W, Di Maio R, González M, Cerecetto H, Cabrera N, Pérez-Montfort R, de Gómez-Puyou MT, Gómez-Puyou A. Alvarez G, et al. Eur J Med Chem. 2010 Dec;45(12):5767-72. doi: 10.1016/j.ejmech.2010.09.034. Epub 2010 Sep 19. Eur J Med Chem. 2010. PMID: 20889239
1,2,4-thiadiazol-5(4H)-ones: a new class of selective inhibitors of Trypanosoma cruzi triosephosphate isomerase. Study of the mechanism of inhibition.
Alvarez G, Aguirre-López B, Cabrera N, Marins EB, Tinoco L, Batthyány CI, de Gómez-Puyou MT, Puyou AG, Pérez-Montfort R, Cerecetto H, González M. Alvarez G, et al. J Enzyme Inhib Med Chem. 2013 Oct;28(5):981-9. doi: 10.3109/14756366.2012.700928. Epub 2012 Jul 18. J Enzyme Inhib Med Chem. 2013. PMID: 22803666
New chemotypes as Trypanosoma cruzi triosephosphate isomerase inhibitors: a deeper insight into the mechanism of inhibition.
Alvarez G, Martínez J, Aguirre-López B, Cabrera N, Pérez-Díaz L, de Gómez-Puyou MT, Gómez-Puyou A, Pérez-Montfort R, Garat B, Merlino A, González M, Cerecetto H. Alvarez G, et al. Among authors: aguirre lopez b. J Enzyme Inhib Med Chem. 2014 Apr;29(2):198-204. doi: 10.3109/14756366.2013.765415. Epub 2013 Feb 13. J Enzyme Inhib Med Chem. 2014. PMID: 23406473
Development of bis-thiazoles as inhibitors of triosephosphate isomerase from Trypanosoma cruzi. Identification of new non-mutagenic agents that are active in vivo.
Álvarez G, Martínez J, Varela J, Birriel E, Cruces E, Gabay M, Leal SM, Escobar P, Aguirre-López B, Cabrera N, Tuena de Gómez-Puyou M, Gómez Puyou A, Pérez-Montfort R, Yaluff G, Torres S, Serna E, Vera de Bilbao N, González M, Cerecetto H. Álvarez G, et al. Among authors: aguirre lopez b. Eur J Med Chem. 2015 Jul 15;100:246-56. doi: 10.1016/j.ejmech.2015.06.018. Epub 2015 Jun 12. Eur J Med Chem. 2015. PMID: 26094151
Potent and Selective Inhibitors of Trypanosoma cruzi Triosephosphate Isomerase with Concomitant Inhibition of Cruzipain: Inhibition of Parasite Growth through Multitarget Activity.
Aguilera E, Varela J, Birriel E, Serna E, Torres S, Yaluff G, de Bilbao NV, Aguirre-López B, Cabrera N, Díaz Mazariegos S, de Gómez-Puyou MT, Gómez-Puyou A, Pérez-Montfort R, Minini L, Merlino A, Cerecetto H, González M, Alvarez G. Aguilera E, et al. Among authors: aguirre lopez b. ChemMedChem. 2016 Jun 20;11(12):1328-38. doi: 10.1002/cmdc.201500385. Epub 2015 Oct 23. ChemMedChem. 2016. PMID: 26492824
Novel and Selective Rhipicephalus microplus Triosephosphate Isomerase Inhibitors with Acaricidal Activity.
Saramago L, Gomes H, Aguilera E, Cerecetto H, González M, Cabrera M, Alzugaray MF, da Silva Vaz Junior I, Nunes da Fonseca R, Aguirre-López B, Cabrera N, Pérez-Montfort R, Merlino A, Moraes J, Álvarez G. Saramago L, et al. Among authors: aguirre lopez b. Vet Sci. 2018 Aug 23;5(3):74. doi: 10.3390/vetsci5030074. Vet Sci. 2018. PMID: 30142944 Free PMC article.
Structural basis of human triosephosphate isomerase deficiency: mutation E104D is related to alterations of a conserved water network at the dimer interface.
Rodríguez-Almazán C, Arreola R, Rodríguez-Larrea D, Aguirre-López B, de Gómez-Puyou MT, Pérez-Montfort R, Costas M, Gómez-Puyou A, Torres-Larios A. Rodríguez-Almazán C, et al. J Biol Chem. 2008 Aug 22;283(34):23254-63. doi: 10.1074/jbc.M802145200. Epub 2008 Jun 18. J Biol Chem. 2008. PMID: 18562316 Free article.
15 results