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Identification and characterization of aspartyl-tRNA synthetase inhibitors against Mycobacterium tuberculosis by an integrated whole-cell target-based approach.
Sci Rep. 2018 Aug 23;8(1):12664. doi: 10.1038/s41598-018-31157-3.
Sci Rep. 2018.
PMID: 30140040
Free PMC article.
Optimization of Hydantoins as Potent Antimycobacterial Decaprenylphosphoryl-β-d-Ribose Oxidase (DprE1) Inhibitors.
Balabon O, Pitta E, Rogacki MK, Meiler E, Casanueva R, Guijarro L, Huss S, Lopez-Roman EM, Santos-Villarejo Á, Augustyns K, Ballell L, Aguirre DB, Bates RH, Cunningham F, Cacho M, Van der Veken P.
Balabon O, et al. Among authors: aguirre db.
J Med Chem. 2020 May 28;63(10):5367-5386. doi: 10.1021/acs.jmedchem.0c00107. Epub 2020 May 13.
J Med Chem. 2020.
PMID: 32342688
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A first-in-class leucyl-tRNA synthetase inhibitor, ganfeborole, for rifampicin-susceptible tuberculosis: a phase 2a open-label, randomized trial.
Diacon AH, Barry CE 3rd, Carlton A, Chen RY, Davies M, de Jager V, Fletcher K, Koh GCKW, Kontsevaya I, Heyckendorf J, Lange C, Reimann M, Penman SL, Scott R, Maher-Edwards G, Tiberi S, Vlasakakis G, Upton CM, Aguirre DB.
Diacon AH, et al. Among authors: aguirre db.
Nat Med. 2024 Mar;30(3):896-904. doi: 10.1038/s41591-024-02829-7. Epub 2024 Feb 16.
Nat Med. 2024.
PMID: 38365949
Free PMC article.
Clinical Trial.
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A novel live vector group A streptococcal emm type 9 vaccine delivered intranasally protects mice against challenge infection with emm type 9 group A streptococci.
Wozniak A, García P, Geoffroy EA, Aguirre DB, González SA, Sarno VA, Dale JB, Salazar-Echegarai FJ, Vera A, Bueno SM, Kalergis AM.
Wozniak A, et al. Among authors: aguirre db.
Clin Vaccine Immunol. 2014 Sep;21(9):1343-9. doi: 10.1128/CVI.00330-14. Epub 2014 Jul 23.
Clin Vaccine Immunol. 2014.
PMID: 25056362
Free PMC article.
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