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Phosphatidylinositol-3,4,5-trisphosphate interacts with alpha-synuclein and initiates its aggregation and formation of Parkinson's disease-related fibril polymorphism.
Choong CJ, Aguirre C, Kakuda K, Beck G, Nakanishi H, Kimura Y, Shimma S, Nabekura K, Hideshima M, Doi J, Yamaguchi K, Nakajima K, Wadayama T, Hayakawa H, Baba K, Ogawa K, Takeuchi T, Badawy SMM, Murayama S, Nagano S, Goto Y, Miyanoiri Y, Nagai Y, Mochizuki H, Ikenaka K. Choong CJ, et al. Among authors: aguirre c. Acta Neuropathol. 2023 May;145(5):573-595. doi: 10.1007/s00401-023-02555-3. Epub 2023 Mar 20. Acta Neuropathol. 2023. PMID: 36939875 Free PMC article.
Structurally distinct α-synuclein fibrils induce robust parkinsonian pathology.
Hayakawa H, Nakatani R, Ikenaka K, Aguirre C, Choong CJ, Tsuda H, Nagano S, Koike M, Ikeuchi T, Hasegawa M, Papa SM, Nagai Y, Mochizuki H, Baba K. Hayakawa H, et al. Among authors: aguirre c. Mov Disord. 2020 Feb;35(2):256-267. doi: 10.1002/mds.27887. Epub 2019 Oct 23. Mov Disord. 2020. PMID: 31643109 Free PMC article.
Polyphenol-solubility alters amyloid fibril formation of α-synuclein.
So M, Kimura Y, Yamaguchi K, Sugiki T, Fujiwara T, Aguirre C, Ikenaka K, Mochizuki H, Kawata Y, Goto Y. So M, et al. Among authors: aguirre c. Protein Sci. 2021 Aug;30(8):1701-1713. doi: 10.1002/pro.4130. Epub 2021 Jun 2. Protein Sci. 2021. PMID: 34046949 Free PMC article.
Isoelectric point-amyloid formation of α-synuclein extends the generality of the solubility and supersaturation-limited mechanism.
Furukawa K, Aguirre C, So M, Sasahara K, Miyanoiri Y, Sakurai K, Yamaguchi K, Ikenaka K, Mochizuki H, Kardos J, Kawata Y, Goto Y. Furukawa K, et al. Among authors: aguirre c. Curr Res Struct Biol. 2020 Apr 5;2:35-44. doi: 10.1016/j.crstbi.2020.03.001. eCollection 2020. Curr Res Struct Biol. 2020. PMID: 34235468 Free PMC article.
Serum asymmetric dimethylarginine level correlates with the progression and prognosis of amyotrophic lateral sclerosis.
Ikenaka K, Maeda Y, Hotta Y, Nagano S, Yamada S, Ito D, Torii R, Kakuda K, Tatebe H, Atsuta N, Aguirre C, Kimura Y, Baba K, Tokuda T, Katsuno M, Kimura K, Sobue G, Mochizuki H. Ikenaka K, et al. Among authors: aguirre c. Eur J Neurol. 2022 May;29(5):1410-1416. doi: 10.1111/ene.15254. Epub 2022 Feb 6. Eur J Neurol. 2022. PMID: 35128793 Free PMC article.
517 results