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The SRC Inhibitor Dasatinib Induces Stem Cell-Like Properties in Head and Neck Cancer Cells that are Effectively Counteracted by the Mithralog EC-8042.
Hermida-Prado F, Villaronga MÁ, Granda-Díaz R, Del-Río-Ibisate N, Santos L, Hermosilla MA, Oro P, Allonca E, Agorreta J, Garmendia I, Tornín J, Perez-Escuredo J, Fuente R, Montuenga LM, Morís F, Rodrigo JP, Rodríguez R, García-Pedrero JM. Hermida-Prado F, et al. Among authors: agorreta j. J Clin Med. 2019 Aug 2;8(8):1157. doi: 10.3390/jcm8081157. J Clin Med. 2019. PMID: 31382448 Free PMC article.
YES1 Drives Lung Cancer Growth and Progression and Predicts Sensitivity to Dasatinib.
Garmendia I, Pajares MJ, Hermida-Prado F, Ajona D, Bértolo C, Sainz C, Lavín A, Remírez AB, Valencia K, Moreno H, Ferrer I, Behrens C, Cuadrado M, Paz-Ares L, Bustelo XR, Gil-Bazo I, Alameda D, Lecanda F, Calvo A, Felip E, Sánchez-Céspedes M, Wistuba II, Granda-Diaz R, Rodrigo JP, García-Pedrero JM, Pio R, Montuenga LM, Agorreta J. Garmendia I, et al. Among authors: agorreta j. Am J Respir Crit Care Med. 2019 Oct 1;200(7):888-899. doi: 10.1164/rccm.201807-1292OC. Am J Respir Crit Care Med. 2019. PMID: 31166114 Free article.
PD-L1 expression correlates with tumor-infiltrating lymphocytes and better prognosis in patients with HPV-negative head and neck squamous cell carcinomas.
Sanchez-Canteli M, Granda-Díaz R, Del Rio-Ibisate N, Allonca E, López-Alvarez F, Agorreta J, Garmendia I, Montuenga LM, García-Pedrero JM, Rodrigo JP. Sanchez-Canteli M, et al. Among authors: agorreta j. Cancer Immunol Immunother. 2020 Oct;69(10):2089-2100. doi: 10.1007/s00262-020-02604-w. Epub 2020 May 24. Cancer Immunol Immunother. 2020. PMID: 32448984 Free PMC article.
SRC family kinase (SFK) inhibitor dasatinib improves the antitumor activity of anti-PD-1 in NSCLC models by inhibiting Treg cell conversion and proliferation.
Redin E, Garmendia I, Lozano T, Serrano D, Senent Y, Redrado M, Villalba M, De Andrea CE, Exposito F, Ajona D, Ortiz-Espinosa S, Remirez A, Bertolo C, Sainz C, Garcia-Pedrero J, Pio R, Lasarte J, Agorreta J, Montuenga LM, Calvo A. Redin E, et al. Among authors: agorreta j. J Immunother Cancer. 2021 Mar;9(3):e001496. doi: 10.1136/jitc-2020-001496. J Immunother Cancer. 2021. PMID: 33658304 Free PMC article.
DSTYK inhibition increases the sensitivity of lung cancer cells to T cell-mediated cytotoxicity.
Valencia K, Echepare M, Teijeira Á, Pasquier A, Bértolo C, Sainz C, Tamayo I, Picabea B, Bosco G, Thomas R, Agorreta J, López-Picazo JM, Frigola J, Amat R, Calvo A, Felip E, Melero I, Montuenga LM. Valencia K, et al. Among authors: agorreta j. J Exp Med. 2022 Dec 5;219(12):e20220726. doi: 10.1084/jem.20220726. Epub 2022 Sep 28. J Exp Med. 2022. PMID: 36169652 Free PMC article.
The oncogenic RNA-binding protein SRSF1 regulates LIG1 in non-small cell lung cancer.
Martínez-Terroba E, Ezponda T, Bértolo C, Sainz C, Remírez A, Agorreta J, Garmendia I, Behrens C, Pio R, Wistuba II, Montuenga LM, Pajares MJ. Martínez-Terroba E, et al. Among authors: agorreta j. Lab Invest. 2018 Dec;98(12):1562-1574. doi: 10.1038/s41374-018-0128-2. Epub 2018 Sep 4. Lab Invest. 2018. PMID: 30181552 Free article.
44 results