Agius L - Search Results

1

The GCKR-P446L gene variant predisposes to raised blood cholesterol and lower blood glucose in the P446L mouse-a model for GCKR rs1260326.

Ford BE, Chachra SS, Rodgers K, Moonira T, Al-Oanzi ZH, Anstee QM, Reeves HL, Schattenberg JM, Fairclough RJ, Smith DM, Tiniakos D, Agius L. Ford BE, et al. Among authors: agius l. Mol Metab. 2023 Jun;72:101722. doi: 10.1016/j.molmet.2023.101722. Epub 2023 Apr 7. Mol Metab. 2023. PMID: 37031802 Free PMC article.

2

The Protective Role of the Carbohydrate Response Element Binding Protein in the Liver: The Metabolite Perspective.

Agius L, Chachra SS, Ford BE. Agius L, et al. Front Endocrinol (Lausanne). 2020 Nov 17;11:594041. doi: 10.3389/fendo.2020.594041. eCollection 2020. Front Endocrinol (Lausanne). 2020. PMID: 33281747 Free PMC article. Review.

3

Renal injury and hepatic effects from the methylimidazolium ionic liquid M8OI in mouse.

Leitch AC, Abdelghany TM, Charlton A, Grigalyte J, Oakley F, Borthwick LA, Reed L, Knox A, Reilly WJ, Agius L, Blain PG, Wright MC. Leitch AC, et al. Among authors: agius l. Ecotoxicol Environ Saf. 2020 Oct 1;202:110902. doi: 10.1016/j.ecoenv.2020.110902. Epub 2020 Jul 4. Ecotoxicol Environ Saf. 2020. PMID: 32634706 Free PMC article.

4

Chronic glucokinase activator treatment activates liver Carbohydrate response element binding protein and improves hepatocyte ATP homeostasis during substrate challenge.

Ford BE, Chachra SS, Alshawi A, Brennan A, Harnor S, Cano C, Baker DJ, Smith DM, Fairclough RJ, Agius L. Ford BE, et al. Among authors: agius l. Diabetes Obes Metab. 2020 Nov;22(11):1985-1994. doi: 10.1111/dom.14111. Epub 2020 Jul 7. Diabetes Obes Metab. 2020. PMID: 32519798

5

The Metformin Mechanism on Gluconeogenesis and AMPK Activation: The Metabolite Perspective.

Agius L, Ford BE, Chachra SS. Agius L, et al. Int J Mol Sci. 2020 May 3;21(9):3240. doi: 10.3390/ijms21093240. Int J Mol Sci. 2020. PMID: 32375255 Free PMC article. Review.

6

BMI is a Better Predictor of Periprosthetic Joint Infection Risk Than Local Measures of Adipose Tissue After TKA.

Shearer J, Agius L, Burke N, Rahardja R, Young SW. Shearer J, et al. Among authors: agius l. J Arthroplasty. 2020 Jun;35(6S):S313-S318. doi: 10.1016/j.arth.2020.01.048. Epub 2020 Jan 24. J Arthroplasty. 2020. PMID: 32139192

7

Metformin lowers glucose 6-phosphate in hepatocytes by activation of glycolysis downstream of glucose phosphorylation.

Moonira T, Chachra SS, Ford BE, Marin S, Alshawi A, Adam-Primus NS, Arden C, Al-Oanzi ZH, Foretz M, Viollet B, Cascante M, Agius L. Moonira T, et al. Among authors: agius l. J Biol Chem. 2020 Mar 6;295(10):3330-3346. doi: 10.1074/jbc.RA120.012533. Epub 2020 Jan 23. J Biol Chem. 2020. PMID: 31974165 Free PMC article.

8

Managing the multiply injured patient: the impact of multidisciplinary teams.

French J, Agius LM, Sandiford NA. French J, et al. Among authors: agius lm. Br J Hosp Med (Lond). 2019 Dec 2;80(12):703-706. doi: 10.12968/hmed.2019.80.12.703. Br J Hosp Med (Lond). 2019. PMID: 31822166 Review.

9

Identification of C-β-d-Glucopyranosyl Azole-Type Inhibitors of Glycogen Phosphorylase That Reduce Glycogenolysis in Hepatocytes: In Silico Design, Synthesis, in Vitro Kinetics, and ex Vivo Studies.

Barr D, Szennyes E, Bokor É, Al-Oanzi ZH, Moffatt C, Kun S, Docsa T, Sipos Á, Davies MP, Mathomes RT, Snape TJ, Agius L, Somsák L, Hayes JM. Barr D, et al. Among authors: agius l. ACS Chem Biol. 2019 Jul 19;14(7):1460-1470. doi: 10.1021/acschembio.9b00172. Epub 2019 Jun 19. ACS Chem Biol. 2019. PMID: 31243960

10

Low metformin causes a more oxidized mitochondrial NADH/NAD redox state in hepatocytes and inhibits gluconeogenesis by a redox-independent mechanism.

Alshawi A, Agius L. Alshawi A, et al. Among authors: agius l. J Biol Chem. 2019 Feb 22;294(8):2839-2853. doi: 10.1074/jbc.RA118.006670. Epub 2018 Dec 27. J Biol Chem. 2019. PMID: 30591586 Free PMC article.

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