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Modification of cysteine 179 of IkappaBalpha kinase by nimbolide leads to down-regulation of NF-kappaB-regulated cell survival and proliferative proteins and sensitization of tumor cells to chemotherapeutic agents.
Gupta SC, Prasad S, Reuter S, Kannappan R, Yadav VR, Ravindran J, Hema PS, Chaturvedi MM, Nair M, Aggarwal BB. Gupta SC, et al. Among authors: aggarwal bb. J Biol Chem. 2010 Nov 12;285(46):35406-17. doi: 10.1074/jbc.M110.161984. Epub 2010 Sep 9. J Biol Chem. 2010. PMID: 20829362 Free PMC article.
Azadirone, a limonoid tetranortriterpene, induces death receptors and sensitizes human cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through a p53 protein-independent mechanism: evidence for the role of the ROS-ERK-CHOP-death receptor pathway.
Gupta SC, Francis SK, Nair MS, Mo YY, Aggarwal BB. Gupta SC, et al. Among authors: aggarwal bb. J Biol Chem. 2013 Nov 8;288(45):32343-32356. doi: 10.1074/jbc.M113.455188. Epub 2013 Sep 27. J Biol Chem. 2013. PMID: 24078627 Free PMC article.
3-Formylchromone interacts with cysteine 38 in p65 protein and with cysteine 179 in IκBα kinase, leading to down-regulation of nuclear factor-κB (NF-κB)-regulated gene products and sensitization of tumor cells.
Yadav VR, Prasad S, Gupta SC, Sung B, Phatak SS, Zhang S, Aggarwal BB. Yadav VR, et al. Among authors: aggarwal bb. J Biol Chem. 2012 Jan 2;287(1):245-256. doi: 10.1074/jbc.M111.274613. Epub 2011 Nov 7. J Biol Chem. 2012. PMID: 22065587 Free PMC article. Retracted.
3-Formylchromone interacts with cysteine 38 in p65 protein and with cysteine 179 in IκBα kinase, leading to down-regulation of nuclear factor-κB (NF-κB)-regulated gene products and sensitization of tumor cells.
Yadav VR, Prasad S, Gupta SC, Sung B, Phatak SS, Zhang S, Aggarwal BB. Yadav VR, et al. Among authors: aggarwal bb. J Biol Chem. 2016 Aug 5;291(32):16926. doi: 10.1074/jbc.A111.274613. J Biol Chem. 2016. PMID: 27496967 Free PMC article. No abstract available.
658 results