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A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models.
Yu X, Li D, Kottur J, Shen Y, Kim HS, Park KS, Tsai YH, Gong W, Wang J, Suzuki K, Parker J, Herring L, Kaniskan HÜ, Cai L, Jain R, Liu J, Aggarwal AK, Wang GG, Jin J. Yu X, et al. Among authors: aggarwal ak. Sci Transl Med. 2021 Sep 29;13(613):eabj1578. doi: 10.1126/scitranslmed.abj1578. Epub 2021 Sep 29. Sci Transl Med. 2021. PMID: 34586829 Free PMC article.
Replication across template T/U by human DNA polymerase-iota.
Jain R, Nair DT, Johnson RE, Prakash L, Prakash S, Aggarwal AK. Jain R, et al. Among authors: aggarwal ak. Structure. 2009 Jul 15;17(7):974-80. doi: 10.1016/j.str.2009.04.011. Structure. 2009. PMID: 19604477 Free PMC article.
Crystallization and preliminary crystallographic analysis of the type IIL restriction enzyme MmeI in complex with DNA.
Callahan SJ, Morgan RD, Jain R, Townson SA, Wilson GG, Roberts RJ, Aggarwal AK. Callahan SJ, et al. Among authors: aggarwal ak. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Oct 1;67(Pt 10):1262-5. doi: 10.1107/S1744309111028041. Epub 2011 Sep 30. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011. PMID: 22102043 Free PMC article.
Human DNA polymerase η is pre-aligned for dNTP binding and catalysis.
Ummat A, Silverstein TD, Jain R, Buku A, Johnson RE, Prakash L, Prakash S, Aggarwal AK. Ummat A, et al. Among authors: aggarwal ak. J Mol Biol. 2012 Jan 27;415(4):627-34. doi: 10.1016/j.jmb.2011.11.038. Epub 2011 Nov 29. J Mol Biol. 2012. PMID: 22154937 Free PMC article.
Structure of the NS3 helicase from Zika virus.
Jain R, Coloma J, García-Sastre A, Aggarwal AK. Jain R, et al. Among authors: aggarwal ak. Nat Struct Mol Biol. 2016 Aug;23(8):752-4. doi: 10.1038/nsmb.3258. Epub 2016 Jul 11. Nat Struct Mol Biol. 2016. PMID: 27399257 Free PMC article.
Structures of NS5 Methyltransferase from Zika Virus.
Coloma J, Jain R, Rajashankar KR, García-Sastre A, Aggarwal AK. Coloma J, et al. Among authors: aggarwal ak. Cell Rep. 2016 Sep 20;16(12):3097-3102. doi: 10.1016/j.celrep.2016.08.091. Epub 2016 Sep 12. Cell Rep. 2016. PMID: 27633330 Free PMC article.
344 results