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Current methods to analyze lysosome morphology, positioning, motility and function.
Barral DC, Staiano L, Guimas Almeida C, Cutler DF, Eden ER, Futter CE, Galione A, Marques ARA, Medina DL, Napolitano G, Settembre C, Vieira OV, Aerts JMFG, Atakpa-Adaji P, Bruno G, Capuozzo A, De Leonibus E, Di Malta C, Escrevente C, Esposito A, Grumati P, Hall MJ, Teodoro RO, Lopes SS, Luzio JP, Monfregola J, Montefusco S, Platt FM, Polishchuck R, De Risi M, Sambri I, Soldati C, Seabra MC. Barral DC, et al. Among authors: aerts jmfg. Traffic. 2022 May;23(5):238-269. doi: 10.1111/tra.12839. Epub 2022 Apr 24. Traffic. 2022. PMID: 35343629 Free PMC article. Review.
The development of a broad-spectrum retaining β-exo-galactosidase activity-based probe.
Kuo CL, Su Q, van den Nieuwendijk AMCH, Beenakker TJM, Offen WA, Willems LI, Boot RG, Sarris AJ, Marques ARA, Codée JDC, van der Marel GA, Florea BI, Davies GJ, Overkleeft HS, Aerts JMFG. Kuo CL, et al. Among authors: aerts jmfg. Org Biomol Chem. 2023 Oct 4;21(38):7813-7820. doi: 10.1039/d3ob01261a. Org Biomol Chem. 2023. PMID: 37724332
Conformational and Electronic Variations in 1,2- and 1,5a-Cyclophellitols and their Impact on Retaining α-Glucosidase Inhibition.
Ofman TP, Heming JJA, Nin-Hill A, Küllmer F, Moran E, Bennett M, Steneker R, Klein AM, Ruijgrok G, Kok K, Armstrong ZWB, Aerts JMFG, van der Marel GA, Rovira C, Davies GJ, Artola M, Codée JDC, Overkleeft HS. Ofman TP, et al. Among authors: aerts jmfg. Chemistry. 2024 Apr 16:e202400723. doi: 10.1002/chem.202400723. Online ahead of print. Chemistry. 2024. PMID: 38623783
Trans-cyclosulfamidate mannose-configured cyclitol allows isoform-dependent inhibition of GH47 α-d-mannosidases through a bump-hole strategy.
Males A, Kok K, Nin-Hill A, de Koster N, van den Beukel S, Beenakker TJM, van der Marel GA, Codée JDC, Aerts JMFG, Overkleeft HS, Rovira C, Davies GJ, Artola M. Males A, et al. Among authors: aerts jmfg. Chem Sci. 2023 Nov 17;14(46):13581-13586. doi: 10.1039/d3sc05016e. eCollection 2023 Nov 29. Chem Sci. 2023. PMID: 38033892 Free PMC article.
Phase-Separated Lipid-Based Nanoparticles: Selective Behavior at the Nano-Bio Interface.
Papadopoulou P, van der Pol R, van Hilten N, van Os WL, Pattipeiluhu R, Arias-Alpizar G, Knol RA, Noteborn W, Moradi MA, Ferraz MJ, Aerts JMFG, Sommerdijk N, Campbell F, Risselada HJ, Sevink GJA, Kros A. Papadopoulou P, et al. Among authors: aerts jmfg. Adv Mater. 2024 Feb;36(6):e2310872. doi: 10.1002/adma.202310872. Epub 2023 Dec 6. Adv Mater. 2024. PMID: 37988682
Fluorescence polarisation activity-based protein profiling for the identification of deoxynojirimycin-type inhibitors selective for lysosomal retaining alpha- and beta-glucosidases.
van der Gracht D, Rowland RJ, Roig-Zamboni V, Ferraz MJ, Louwerse M, Geurink PP, Aerts JMFG, Sulzenbacher G, Davies GJ, Overkleeft HS, Artola M. van der Gracht D, et al. Among authors: aerts jmfg. Chem Sci. 2023 Aug 8;14(34):9136-9144. doi: 10.1039/d3sc01021j. eCollection 2023 Aug 30. Chem Sci. 2023. PMID: 37655021 Free PMC article.
Gaucher disease protects against tuberculosis.
Fan J, Hale VL, Lelieveld LT, Whitworth LJ, Busch-Nentwich EM, Troll M, Edelstein PH, Cox TM, Roca FJ, Aerts JMFG, Ramakrishnan L. Fan J, et al. Among authors: aerts jmfg. Proc Natl Acad Sci U S A. 2023 Feb 14;120(7):e2217673120. doi: 10.1073/pnas.2217673120. Epub 2023 Feb 6. Proc Natl Acad Sci U S A. 2023. PMID: 36745788 Free PMC article.
227 results