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Translatability of findings from cynomolgus monkey to human suggests a mechanistic role for IL-21 in promoting immunogenicity to an anti-PD-1/IL-21 mutein fusion protein.
Kroenke MA, Starcevic Manning M, Zuch de Zafra CL, Zhang X, Cook KD, Archer M, Lolkema MP, Wang J, Hoofring S, Saini G, Aeffner F, Ahern E, Cabanas EG, Govindan R, Hui M, Gupta S, Mytych DT. Kroenke MA, et al. Among authors: aeffner f. Front Immunol. 2024 Jan 26;15:1345473. doi: 10.3389/fimmu.2024.1345473. eCollection 2024. Front Immunol. 2024. PMID: 38343535 Free PMC article.
AMG 509 (Xaluritamig), an Anti-STEAP1 XmAb 2+1 T-cell Redirecting Immune Therapy with Avidity-Dependent Activity against Prostate Cancer.
Nolan-Stevaux O, Li C, Liang L, Zhan J, Estrada J, Osgood T, Li F, Zhang H, Case R, Murawsky CM, Estes B, Moore GL, Bernett MJ, Muchhal U, Desjarlais JR, Staley BK, Stevens J, Cooke KS, Aeffner F, Thomas O, Stieglmaier J, Lee JL, Coxon A, Bailis JM. Nolan-Stevaux O, et al. Among authors: aeffner f. Cancer Discov. 2024 Jan 12;14(1):90-103. doi: 10.1158/2159-8290.CD-23-0984. Cancer Discov. 2024. PMID: 37861452
Histopathology and levels of proteins in plasma associate with survival after colorectal cancer diagnosis.
Magnusson MI, Agnarsson BA, Jonasson JG, Tryggvason T, Aeffner F, le Roux L, Magnusdottir DN, Gunnarsdottir HS, Alexíusdóttir KK, Gunnarsdottir K, Söebech E, Runarsdottir H, Jonsdottir EM, Kristinsdottir BS, Olafsson S, Knutsdottir H, Thorsteinsdottir U, Ulfarsson MO, Gudbjartsson DF, Saemundsdottir J, Magnusson OT, Norddahl GL, Watson JEV, Rafnar T, Lund SH, Stefansson K. Magnusson MI, et al. Among authors: aeffner f. Br J Cancer. 2023 Oct;129(7):1142-1151. doi: 10.1038/s41416-023-02374-z. Epub 2023 Aug 18. Br J Cancer. 2023. PMID: 37596405 Free PMC article.
Scientific and Regulatory Policy Committee Points to Consider: Primary Digital Histopathology Evaluation and Peer Review for Good Laboratory Practice (GLP) Nonclinical Toxicology Studies.
Forest T, Aeffner F, Bangari DS, Bawa B, Carter J, Fikes J, High W, Hayashi SM, Jacobsen M, McKinney L, Rudmann D, Steinbach T, Schumacher V, Turner O, Ward JM, Willson CJ. Forest T, et al. Among authors: aeffner f. Toxicol Pathol. 2022 Jun;50(4):531-543. doi: 10.1177/01926233221099273. Epub 2022 Jun 3. Toxicol Pathol. 2022. PMID: 35657014
Scientific and Regulatory Policy Committee Brief Communication: 2019 Survey on Use of Digital Histopathology Systems in Nonclinical Toxicology Studies.
Forest T, Aeffner F, Bangari DS, Bawa B, Carter J, Fikes J, High WB, Hayashi SM, Jacobsen M, McKinney L, Rudmann D, Steinbach T, Schumacher V, Turner OC, Ward JM, Willson CJ. Forest T, et al. Among authors: aeffner f. Toxicol Pathol. 2022 Apr;50(3):397-401. doi: 10.1177/01926233221084621. Epub 2022 Mar 23. Toxicol Pathol. 2022. PMID: 35321602
Immunotherapy combinations overcome resistance to bispecific T cell engager treatment in T cell-cold solid tumors.
Belmontes B, Sawant DV, Zhong W, Tan H, Kaul A, Aeffner F, O'Brien SA, Chun M, Noubade R, Eng J, Ma H, Muenz M, Li P, Alba BM, Thomas M, Cook K, Wang X, DeVoss J, Egen JG, Nolan-Stevaux O. Belmontes B, et al. Among authors: aeffner f. Sci Transl Med. 2021 Aug 25;13(608):eabd1524. doi: 10.1126/scitranslmed.abd1524. Sci Transl Med. 2021. PMID: 34433637
Preclinical Assessment of a MUC12-Targeted BiTE (Bispecific T-cell Engager) Molecule.
Pham E, Friedrich M, Aeffner F, Lutteropp M, Mariano NF, Deegen P, Dahlhoff C, Vogel F, Bluemel C, Harrold JM, Brandl C, Grinberg N, Rattel B, Coxon A, Bailis JM. Pham E, et al. Among authors: aeffner f. Mol Cancer Ther. 2021 Oct;20(10):1977-1987. doi: 10.1158/1535-7163.MCT-21-0236. Epub 2021 Aug 10. Mol Cancer Ther. 2021. PMID: 34376583
44 results