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Page 1
An Isoquinoline Scaffold as a Novel Class of Allosteric HIV-1 Integrase Inhibitors.
Wilson TA, Koneru PC, Rebensburg SV, Lindenberger JJ, Kobe MJ, Cockroft NT, Adu-Ampratwum D, Larue RC, Kvaratskhelia M, Fuchs JR. Wilson TA, et al. Among authors: adu ampratwum d. ACS Med Chem Lett. 2019 Jan 30;10(2):215-220. doi: 10.1021/acsmedchemlett.8b00633. eCollection 2019 Feb 14. ACS Med Chem Lett. 2019. PMID: 30783506 Free PMC article.
Structural and mechanistic bases for a potent HIV-1 capsid inhibitor.
Bester SM, Wei G, Zhao H, Adu-Ampratwum D, Iqbal N, Courouble VV, Francis AC, Annamalai AS, Singh PK, Shkriabai N, Van Blerkom P, Morrison J, Poeschla EM, Engelman AN, Melikyan GB, Griffin PR, Fuchs JR, Asturias FJ, Kvaratskhelia M. Bester SM, et al. Among authors: adu ampratwum d. Science. 2020 Oct 16;370(6514):360-364. doi: 10.1126/science.abb4808. Science. 2020. PMID: 33060363 Free PMC article.
Identification and Optimization of a Novel HIV-1 Integrase Inhibitor.
Adu-Ampratwum D, Pan Y, Koneru PC, Antwi J, Hoyte AC, Kessl J, Griffin PR, Kvaratskhelia M, Fuchs JR, Larue RC. Adu-Ampratwum D, et al. ACS Omega. 2022 Jan 24;7(5):4482-4491. doi: 10.1021/acsomega.1c06378. eCollection 2022 Feb 8. ACS Omega. 2022. PMID: 35155940 Free PMC article.
Tomatidine targets ATF4-dependent signaling and induces ferroptosis to limit pancreatic cancer progression.
Mukherjee D, Chakraborty S, Bercz L, D'Alesio L, Wedig J, Torok MA, Pfau T, Lathrop H, Jasani S, Guenther A, McGue J, Adu-Ampratwum D, Fuchs JR, Frankel TL, Pietrzak M, Culp S, Strohecker AM, Skardal A, Mace TA. Mukherjee D, et al. Among authors: adu ampratwum d. iScience. 2023 Jul 17;26(8):107408. doi: 10.1016/j.isci.2023.107408. eCollection 2023 Aug 18. iScience. 2023. PMID: 37554459 Free PMC article.
Synthesis of the C22-C40 Domain of the Azaspiracids.
Zhang Z, Chen Y, Adu-Ampratwum D, Okumu AA, Kenton NT, Forsyth CJ. Zhang Z, et al. Among authors: adu ampratwum d. Org Lett. 2016 Apr 15;18(8):1824-7. doi: 10.1021/acs.orglett.6b00557. Epub 2016 Apr 4. Org Lett. 2016. PMID: 27043010
Stereochemical Definition of the Natural Product (6R,10R,13R, 14R,16R,17R,19S,20S,21R,24S,25S,28S,30S,32R,33R,34R,36S,37S,39R)-Azaspiracid-3 by Total Synthesis and Comparative Analyses.
Kenton NT, Adu-Ampratwum D, Okumu AA, McCarron P, Kilcoyne J, Rise F, Wilkins AL, Miles CO, Forsyth CJ. Kenton NT, et al. Among authors: adu ampratwum d. Angew Chem Int Ed Engl. 2018 Jan 15;57(3):810-813. doi: 10.1002/anie.201711008. Epub 2017 Dec 15. Angew Chem Int Ed Engl. 2018. PMID: 29193497
Total Synthesis of (6R,10R,13R,14R,16R,17R,19S,20R,21R,24S, 25S,28S,30S,32R,33R,34R,36S,37S,39R)-Azaspiracid-3 Reveals Non-Identity with the Natural Product.
Kenton NT, Adu-Ampratwum D, Okumu AA, Zhang Z, Chen Y, Nguyen S, Xu J, Ding Y, McCarron P, Kilcoyne J, Rise F, Wilkins AL, Miles CO, Forsyth CJ. Kenton NT, et al. Among authors: adu ampratwum d. Angew Chem Int Ed Engl. 2018 Jan 15;57(3):805-809. doi: 10.1002/anie.201711006. Epub 2017 Dec 13. Angew Chem Int Ed Engl. 2018. PMID: 29193614