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FXR agonists in NASH treatment.
Adorini L, Trauner M. Adorini L, et al. J Hepatol. 2023 Nov;79(5):1317-1331. doi: 10.1016/j.jhep.2023.07.034. Epub 2023 Aug 9. J Hepatol. 2023. PMID: 37562746 Free article. Review.
Farnesoid X receptor enhances epithelial ACE2 expression and inhibits virally induced IL-6 secretion: implications for intestinal symptoms of SARS-CoV-2.
Smyth JS, Truong JK, Rao A, Lin R, Foulke-Abel J, Adorini L, Donowitz M, Dawson PA, Keely SJ. Smyth JS, et al. Among authors: adorini l. Am J Physiol Gastrointest Liver Physiol. 2023 Nov 1;325(5):G446-G452. doi: 10.1152/ajpgi.00099.2023. Epub 2023 Sep 12. Am J Physiol Gastrointest Liver Physiol. 2023. PMID: 37697930 Free article.
The role of FXR and TGR5 in reversing and preventing progression of Western diet-induced hepatic steatosis, inflammation, and fibrosis in mice.
Wang XX, Xie C, Libby AE, Ranjit S, Levi J, Myakala K, Bhasin K, Jones BA, Orlicky DJ, Takahashi S, Dvornikov A, Kleiner DE, Hewitt SM, Adorini L, Kopp JB, Krausz KW, Rosenberg A, McManaman JL, Robertson CE, Ir D, Frank DN, Luo Y, Gonzalez FJ, Gratton E, Levi M. Wang XX, et al. Among authors: adorini l. J Biol Chem. 2022 Nov;298(11):102530. doi: 10.1016/j.jbc.2022.102530. Epub 2022 Oct 7. J Biol Chem. 2022. PMID: 36209823 Free PMC article.
Farnesoid X receptor activation by the novel agonist TC-100 (3α, 7α, 11β-Trihydroxy-6α-ethyl-5β-cholan-24-oic Acid) preserves the intestinal barrier integrity and promotes intestinal microbial reshaping in a mouse model of obstructed bile acid flow.
Marzano M, Fosso B, Colliva C, Notario E, Passeri D, Intranuovo M, Gioiello A, Adorini L, Pesole G, Pellicciari R, Moschetta A, Gadaleta RM. Marzano M, et al. Among authors: adorini l. Biomed Pharmacother. 2022 Sep;153:113380. doi: 10.1016/j.biopha.2022.113380. Epub 2022 Jul 19. Biomed Pharmacother. 2022. PMID: 36076475 Free article.
332 results