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The nose is the best niche for detection of experimental pneumococcal colonisation in adults of all ages, using nasal wash.
Nikolaou E, German EL, Blizard A, Howard A, Hitchins L, Chen T, Chadwick J, Pojar S, Mitsi E, Solórzano C, Sunny S, Dunne F, Gritzfeld JF, Adler H, Hinds J, Gould KA, Rylance J, Collins AM, Gordon SB, Ferreira DM. Nikolaou E, et al. Among authors: adler h. Sci Rep. 2021 Sep 14;11(1):18279. doi: 10.1038/s41598-021-97807-1. Sci Rep. 2021. PMID: 34521967 Free PMC article.
Novel Analysis of Immune Cells from Nasal Microbiopsy Demonstrates Reliable, Reproducible Data for Immune Populations, and Superior Cytokine Detection Compared to Nasal Wash.
Jochems SP, Piddock K, Rylance J, Adler H, Carniel BF, Collins A, Gritzfeld JF, Hancock C, Hill H, Reiné J, Seddon A, Solórzano C, Sunny S, Trimble A, Wright AD, Zaidi S, Gordon SB, Ferreira DM. Jochems SP, et al. Among authors: adler h. PLoS One. 2017 Jan 20;12(1):e0169805. doi: 10.1371/journal.pone.0169805. eCollection 2017. PLoS One. 2017. PMID: 28107457 Free PMC article.
Pneumococcal Capsular Polysaccharide Immunity in the Elderly.
Adler H, Ferreira DM, Gordon SB, Rylance J. Adler H, et al. Clin Vaccine Immunol. 2017 Jun 5;24(6):e00004-17. doi: 10.1128/CVI.00004-17. Print 2017 Jun. Clin Vaccine Immunol. 2017. PMID: 28424198 Free PMC article. Review.
Hands are vehicles for transmission of Streptococcus pneumoniae in novel controlled human infection study.
Connor V, German E, Pojar S, Mitsi E, Hales C, Nikolaou E, Hyder-Wright A, Adler H, Zaidi S, Hill H, Jochems SP, Burhan H, French N, Tobery T, Rylance J, Ferreira DM. Connor V, et al. Among authors: adler h. Eur Respir J. 2018 Oct 10;52(4):1800599. doi: 10.1183/13993003.00599-2018. Print 2018 Oct. Eur Respir J. 2018. PMID: 30305331 Free article. No abstract available.
Inflammation induced by influenza virus impairs human innate immune control of pneumococcus.
Jochems SP, Marcon F, Carniel BF, Holloway M, Mitsi E, Smith E, Gritzfeld JF, Solórzano C, Reiné J, Pojar S, Nikolaou E, German EL, Hyder-Wright A, Hill H, Hales C, de Steenhuijsen Piters WAA, Bogaert D, Adler H, Zaidi S, Connor V, Gordon SB, Rylance J, Nakaya HI, Ferreira DM. Jochems SP, et al. Among authors: adler h. Nat Immunol. 2018 Dec;19(12):1299-1308. doi: 10.1038/s41590-018-0231-y. Epub 2018 Oct 29. Nat Immunol. 2018. PMID: 30374129 Free PMC article. Clinical Trial.
Pneumococcal Colonization in Healthy Adult Research Participants in the Conjugate Vaccine Era, United Kingdom, 2010-2017.
Adler H, Nikolaou E, Gould K, Hinds J, Collins AM, Connor V, Hales C, Hill H, Hyder-Wright AD, Zaidi SR, German EL, Gritzfeld JF, Mitsi E, Pojar S, Gordon SB, Roberts AP, Rylance J, Ferreira DM. Adler H, et al. J Infect Dis. 2019 May 24;219(12):1989-1993. doi: 10.1093/infdis/jiz034. J Infect Dis. 2019. PMID: 30690468 Free PMC article.
Symptoms associated with influenza vaccination and experimental human pneumococcal colonisation of the nasopharynx.
Hales C, Jochems SP, Robinson R, Solórzano C, Carniel B, Pojar S, Reiné J, German EL, Nikolaou E, Mitsi E, Hyder-Wright AD, Hill H, Adler H, Connor V, Zaidi S, Lowe C, Fan X, Wang D, Gordon SB, Rylance J, Ferreira DM. Hales C, et al. Among authors: adler h. Vaccine. 2020 Feb 28;38(10):2298-2306. doi: 10.1016/j.vaccine.2020.01.070. Epub 2020 Feb 5. Vaccine. 2020. PMID: 32035708 Free PMC article. Clinical Trial.
Upper airways colonisation of Streptococcus pneumoniae in adults aged 60 years and older: A systematic review of prevalence and individual participant data meta-analysis of risk factors.
Smith EL, Wheeler I, Adler H, Ferreira DM, Sá-Leão R, Abdullahi O, Adetifa I, Becker-Dreps S, Esposito S, Farida H, Kandasamy R, Mackenzie GA, Nuorti JP, Nzenze S, Madhi SA, Ortega O, Roca A, Safari D, Schaumburg F, Usuf E, Sanders EAM, Grant LR, Hammitt LL, O'Brien KL, Gounder P, Bruden DJT, Stanton MC, Rylance J. Smith EL, et al. Among authors: adler h. J Infect. 2020 Oct;81(4):540-548. doi: 10.1016/j.jinf.2020.06.028. Epub 2020 Jun 17. J Infect. 2020. PMID: 32562794 Free PMC article.
Experimental Human Pneumococcal Colonization in Older Adults Is Feasible and Safe, Not Immunogenic.
Adler H, German EL, Mitsi E, Nikolaou E, Pojar S, Hales C, Robinson R, Connor V, Hill H, Hyder-Wright AD, Lazarova L, Lowe C, Smith EL, Wheeler I, Zaidi SR, Jochems SP, Loukov D, Reiné J, Solórzano-Gonzalez C, de Gorguette d'Argoeuves P, Jones T, Goldblatt D, Chen T, Aston SJ, French N, Collins AM, Gordon SB, Ferreira DM, Rylance J. Adler H, et al. Am J Respir Crit Care Med. 2021 Mar 1;203(5):604-613. doi: 10.1164/rccm.202004-1483OC. Am J Respir Crit Care Med. 2021. PMID: 32941735 Free PMC article.
Experimental Human Challenge Defines Distinct Pneumococcal Kinetic Profiles and Mucosal Responses between Colonized and Non-Colonized Adults.
Nikolaou E, Jochems SP, Mitsi E, Pojar S, Blizard A, Reiné J, Solórzano C, Negera E, Carniel B, Soares-Schanoski A, Connor V, Adler H, Zaidi SR, Hales C, Hill H, Hyder-Wright A, Gordon SB, Rylance J, Ferreira DM. Nikolaou E, et al. Among authors: adler h. mBio. 2021 Jan 12;12(1):e02020-20. doi: 10.1128/mBio.02020-20. mBio. 2021. PMID: 33436429 Free PMC article.
515 results