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Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls.
Acta Pharm Sin B. 2021 Dec;11(12):3740-3755. doi: 10.1016/j.apsb.2021.09.023. Epub 2021 Sep 30.
Acta Pharm Sin B. 2021.
PMID: 35024303
Free PMC article.
Review.
Ferroptosis and Acetaminophen Hepatotoxicity: Are We Going Down Another Rabbit Hole?
Jaeschke H, Adelusi OB, Ramachandran A.
Jaeschke H, et al. Among authors: adelusi ob.
Gene Expr. 2021 Jun 11;20(3):169-178. doi: 10.3727/105221621X16104581979144. Epub 2021 Jan 13.
Gene Expr. 2021.
PMID: 33441220
Free PMC article.
Review.
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Human Wharton's Jelly-derived mesenchymal stem cells prevent acetaminophen-induced liver injury in a mouse model unlike human dermal fibroblasts.
Umbaugh DS, Soder RP, Nguyen NT, Adelusi O, Robarts DR, Woolbright B, Duan L, Abhyankar S, Dawn B, Apte U, Jaeschke H, Ramachandran A.
Umbaugh DS, et al.
Arch Toxicol. 2022 Dec;96(12):3315-3329. doi: 10.1007/s00204-022-03372-5. Epub 2022 Sep 4.
Arch Toxicol. 2022.
PMID: 36057886
Free PMC article.
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The role of Iron in lipid peroxidation and protein nitration during acetaminophen-induced liver injury in mice.
Adelusi OB, Ramachandran A, Lemasters JJ, Jaeschke H.
Adelusi OB, et al.
Toxicol Appl Pharmacol. 2022 Jun 15;445:116043. doi: 10.1016/j.taap.2022.116043. Epub 2022 May 2.
Toxicol Appl Pharmacol. 2022.
PMID: 35513057
Free PMC article.
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Recovered Hepatocytes Promote Macrophage Apoptosis Through CXCR4 After Acetaminophen-Induced Liver Injury in Mice.
Nguyen NT, Umbaugh DS, Huang EL, Adelusi OB, Sanchez Guerrero G, Ramachandran A, Jaeschke H.
Nguyen NT, et al. Among authors: adelusi ob.
Toxicol Sci. 2022 Jul 28;188(2):248-260. doi: 10.1093/toxsci/kfac057.
Toxicol Sci. 2022.
PMID: 35642939
Free PMC article.
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The thrombopoietin mimetic JNJ-26366821 reduces the late injury and accelerates the onset of liver recovery after acetaminophen-induced liver injury in mice.
Adelusi OB, Akakpo JY, Eichenbaum G, Sadaff E, Ramachandran A, Jaeschke H.
Adelusi OB, et al.
Arch Toxicol. 2024 Jun;98(6):1843-1858. doi: 10.1007/s00204-024-03725-2. Epub 2024 Mar 29.
Arch Toxicol. 2024.
PMID: 38551724
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Dose-dependent pleiotropic role of neutrophils during acetaminophen-induced liver injury in male and female mice.
Nguyen NT, Umbaugh DS, Smith S, Adelusi OB, Sanchez-Guerrero G, Ramachandran A, Jaeschke H.
Nguyen NT, et al. Among authors: adelusi ob.
Arch Toxicol. 2023 May;97(5):1397-1412. doi: 10.1007/s00204-023-03478-4. Epub 2023 Mar 16.
Arch Toxicol. 2023.
PMID: 36928416
Free PMC article.
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