Adachi T - Search Results

1

Optimization Efforts for Identification of Novel Highly Potent Keap1-Nrf2 Protein-Protein Interaction Inhibitors.

Otake K, Hara Y, Ubukata M, Inoue M, Nagahashi N, Motoda D, Ogawa N, Hantani Y, Hantani R, Adachi T, Nomura A, Yamaguchi K, Maekawa M, Mamada H, Motomura T, Sato M, Harada K. Otake K, et al. Among authors: adachi t. J Med Chem. 2024 Mar 14;67(5):3741-3763. doi: 10.1021/acs.jmedchem.3c02171. Epub 2024 Feb 26. J Med Chem. 2024. PMID: 38408347

2

Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1-Nrf2 PPI Inhibitor.

Otake K, Ubukata M, Nagahashi N, Ogawa N, Hantani Y, Hantani R, Adachi T, Nomura A, Yamaguchi K, Maekawa M, Mamada H, Motomura T, Sato M, Harada K. Otake K, et al. Among authors: adachi t. ACS Med Chem Lett. 2023 Apr 7;14(5):658-665. doi: 10.1021/acsmedchemlett.3c00067. eCollection 2023 May 11. ACS Med Chem Lett. 2023. PMID: 37197451 Free PMC article.

3

Screening approaches for the identification of Nrf2-Keap1 protein-protein interaction inhibitors targeting hot spot residues.

Asano W, Hantani R, Uhara T, Debaene F, Nomura A, Yamaguchi K, Adachi T, Otake K, Harada K, Hantani Y. Asano W, et al. Among authors: adachi t. SLAS Discov. 2024 Mar;29(2):100125. doi: 10.1016/j.slasd.2023.11.001. Epub 2023 Nov 5. SLAS Discov. 2024. PMID: 37935317 Free article.

4

Discovery of Selective Transforming Growth Factor β Type II Receptor Inhibitors as Antifibrosis Agents.

Miwa S, Yokota M, Ueyama Y, Maeda K, Ogoshi Y, Seki N, Ogawa N, Nishihata J, Nomura A, Adachi T, Kitao Y, Nozawa K, Ishikawa T, Ukaji Y, Shiozaki M. Miwa S, et al. Among authors: adachi t. ACS Med Chem Lett. 2021 Apr 21;12(5):745-751. doi: 10.1021/acsmedchemlett.0c00679. eCollection 2021 May 13. ACS Med Chem Lett. 2021. PMID: 34055221 Free PMC article.

5

Fragment-based lead discovery to identify novel inhibitors that target the ATP binding site of pyruvate dehydrogenase kinases.

Akaki T, Bessho Y, Ito T, Fujioka S, Ubukata M, Mori G, Yamanaka K, Orita T, Doi S, Iwanaga T, Ikegashira K, Hantani Y, Nakanishi I, Adachi T. Akaki T, et al. Among authors: adachi t. Bioorg Med Chem. 2021 Aug 15;44:116283. doi: 10.1016/j.bmc.2021.116283. Epub 2021 Jul 8. Bioorg Med Chem. 2021. PMID: 34274549

6

Structure-based drug design of novel and highly potent pyruvate dehydrogenase kinase inhibitors.

Bessho Y, Akaki T, Hara Y, Yamakawa M, Obika S, Mori G, Ubukata M, Yasue K, Nakane Y, Terasako Y, Orita T, Doi S, Iwanaga T, Fujishima A, Adachi T, Ueno H, Motomura T. Bessho Y, et al. Among authors: adachi t. Bioorg Med Chem. 2021 Dec 15;52:116514. doi: 10.1016/j.bmc.2021.116514. Epub 2021 Nov 10. Bioorg Med Chem. 2021. PMID: 34808405

7

Discovery and SAR of JTE-151: A Novel RORγ Inhibitor for Clinical Development.

Maeba T, Hirata K, Kotoku M, Seki N, Maeda K, Hirashima S, Yamanaka H, Sakai T, Obika S, Hori A, Hara Y, Noji S, Suwa Y, Yokota M, Fujioka S, Yamaguchi T, Katsuda Y, Hata T, Miyagawa N, Arita K, Nomura Y, Taniguchi T, Asahina K, Aratsu Y, Naka Y, Adachi T, Nomura A, Akai S, Oshida SI, Pai S, Crowe P, Bradley E, Steensma R, Tao H, Fenn M, Babine R, Li X, Thacher S, Soeta T, Ukaji Y, Shiozaki M. Maeba T, et al. Among authors: adachi t. J Med Chem. 2024 Jan 25;67(2):952-970. doi: 10.1021/acs.jmedchem.3c01933. Epub 2024 Jan 3. J Med Chem. 2024. PMID: 38170624

8

Discovery of a Janus Kinase Inhibitor Bearing a Highly Three-Dimensional Spiro Scaffold: JTE-052 (Delgocitinib) as a New Dermatological Agent to Treat Inflammatory Skin Disorders.

Noji S, Hara Y, Miura T, Yamanaka H, Maeda K, Hori A, Yamamoto H, Obika S, Inoue M, Hase Y, Orita T, Doi S, Adachi T, Tanimoto A, Oki C, Kimoto Y, Ogawa Y, Negoro T, Hashimoto H, Shiozaki M. Noji S, et al. Among authors: adachi t. J Med Chem. 2020 Jul 9;63(13):7163-7185. doi: 10.1021/acs.jmedchem.0c00450. Epub 2020 Jun 29. J Med Chem. 2020. PMID: 32511913

9

Discovery of conformationally constrained tetracyclic compounds as potent hepatitis C virus NS5B RNA polymerase inhibitors.

Ikegashira K, Oka T, Hirashima S, Noji S, Yamanaka H, Hara Y, Adachi T, Tsuruha J, Doi S, Hase Y, Noguchi T, Ando I, Ogura N, Ikeda S, Hashimoto H. Ikegashira K, et al. Among authors: adachi t. J Med Chem. 2006 Nov 30;49(24):6950-3. doi: 10.1021/jm0610245. J Med Chem. 2006. PMID: 17125247

10

Fragment-Based Discovery of Novel VE-PTP Inhibitors Using Orthogonal Biophysical Techniques.

Asano W, Yamanaka K, Ohara Y, Uhara T, Doi S, Orita T, Iwanaga T, Adachi T, Fujioka S, Akaki T, Ikegashira K, Hantani Y. Asano W, et al. Among authors: adachi t. Biochemistry. 2023 Jul 18;62(14):2161-2169. doi: 10.1021/acs.biochem.3c00079. Epub 2023 Jul 6. Biochemistry. 2023. PMID: 37414577

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