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Discovery of senolytics using machine learning.
Smer-Barreto V, Quintanilla A, Elliott RJR, Dawson JC, Sun J, Campa VM, Lorente-Macías Á, Unciti-Broceta A, Carragher NO, Acosta JC, Oyarzún DA. Smer-Barreto V, et al. Among authors: acosta jc. Nat Commun. 2023 Jun 10;14(1):3445. doi: 10.1038/s41467-023-39120-1. Nat Commun. 2023. PMID: 37301862 Free PMC article.
Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence.
Fernández-Duran I, Quintanilla A, Tarrats N, Birch J, Hari P, Millar FR, Lagnado AB, Smer-Barreto V, Muir M, Brunton VG, Passos JF, Acosta JC. Fernández-Duran I, et al. Among authors: acosta jc. Cell Death Differ. 2022 Jun;29(6):1267-1282. doi: 10.1038/s41418-021-00917-6. Epub 2021 Dec 16. Cell Death Differ. 2022. PMID: 34916628 Free PMC article.
Toll-like receptor 2 orchestrates a tumor suppressor response in non-small cell lung cancer.
Millar FR, Pennycuick A, Muir M, Quintanilla A, Hari P, Freyer E, Gautier P, Meynert A, Grimes G, Coll CS, Zdral S, Victorelli S, Teixeira VH, Connelly J, Passos JF, Ros MA, Wallace WAH, Frame MC, Sims AH, Boulter L, Janes SM, Wilkinson S, Acosta JC. Millar FR, et al. Among authors: acosta jc. Cell Rep. 2022 Nov 8;41(6):111596. doi: 10.1016/j.celrep.2022.111596. Cell Rep. 2022. PMID: 36351380 Free PMC article.
Paracrine cellular senescence exacerbates biliary injury and impairs regeneration.
Ferreira-Gonzalez S, Lu WY, Raven A, Dwyer B, Man TY, O'Duibhir E, Lewis PJS, Campana L, Kendall TJ, Bird TG, Tarrats N, Acosta JC, Boulter L, Forbes SJ. Ferreira-Gonzalez S, et al. Among authors: acosta jc. Nat Commun. 2018 Mar 9;9(1):1020. doi: 10.1038/s41467-018-03299-5. Nat Commun. 2018. PMID: 29523787 Free PMC article.
Notch Signaling Mediates Secondary Senescence.
Teo YV, Rattanavirotkul N, Olova N, Salzano A, Quintanilla A, Tarrats N, Kiourtis C, Müller M, Green AR, Adams PD, Acosta JC, Bird TG, Kirschner K, Neretti N, Chandra T. Teo YV, et al. Among authors: acosta jc. Cell Rep. 2019 Apr 23;27(4):997-1007.e5. doi: 10.1016/j.celrep.2019.03.104. Cell Rep. 2019. PMID: 31018144 Free PMC article.
PHD3 Regulates p53 Protein Stability by Hydroxylating Proline 359.
Rodriguez J, Herrero A, Li S, Rauch N, Quintanilla A, Wynne K, Krstic A, Acosta JC, Taylor C, Schlisio S, von Kriegsheim A. Rodriguez J, et al. Among authors: acosta jc. Cell Rep. 2018 Jul 31;24(5):1316-1329. doi: 10.1016/j.celrep.2018.06.108. Cell Rep. 2018. PMID: 30067985 Free PMC article.
MYC sensitises cells to apoptosis by driving energetic demand.
Edwards-Hicks J, Su H, Mangolini M, Yoneten KK, Wills J, Rodriguez-Blanco G, Young C, Cho K, Barker H, Muir M, Guerrieri AN, Li XF, White R, Manasterski P, Mandrou E, Wills K, Chen J, Abraham E, Sateri K, Qian BZ, Bankhead P, Arends M, Gammoh N, von Kriegsheim A, Patti GJ, Sims AH, Acosta JC, Brunton V, Kranc KR, Christophorou M, Pearce EL, Ringshausen I, Finch AJ. Edwards-Hicks J, et al. Among authors: acosta jc. Nat Commun. 2022 Aug 9;13(1):4674. doi: 10.1038/s41467-022-32368-z. Nat Commun. 2022. PMID: 35945217 Free PMC article.
Senolytic treatment preserves biliary regenerative capacity lost through cellular senescence during cold storage.
Ferreira-Gonzalez S, Man TY, Esser H, Aird R, Kilpatrick AM, Rodrigo-Torres D, Younger N, Campana L, Gadd VL, Dwyer B, Aleksieva N, Boulter L, Macmillan MT, Wang Y, Mylonas KJ, Ferenbach DA, Kendall TJ, Lu WY, Acosta JC, Kurian D, O'Neill S, Oniscu GC, Banales JM, Krimpenfort PJ, Forbes SJ. Ferreira-Gonzalez S, et al. Among authors: acosta jc. Sci Transl Med. 2022 Dec 7;14(674):eabj4375. doi: 10.1126/scitranslmed.abj4375. Epub 2022 Dec 7. Sci Transl Med. 2022. PMID: 36475903
84 results