Acker TM - Search Results

1

Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases.

Guo CJ, Chang FY, Wyche TP, Backus KM, Acker TM, Funabashi M, Taketani M, Donia MS, Nayfach S, Pollard KS, Craik CS, Cravatt BF, Clardy J, Voigt CA, Fischbach MA. Guo CJ, et al. Among authors: acker tm. Cell. 2017 Jan 26;168(3):517-526.e18. doi: 10.1016/j.cell.2016.12.021. Epub 2017 Jan 19. Cell. 2017. PMID: 28111075 Free PMC article.

2

Current and potential treatments for ubiquitous but neglected herpesvirus infections.

Gable JE, Acker TM, Craik CS. Gable JE, et al. Among authors: acker tm. Chem Rev. 2014 Nov 26;114(22):11382-412. doi: 10.1021/cr500255e. Epub 2014 Oct 2. Chem Rev. 2014. PMID: 25275644 Free PMC article. Review. No abstract available.

3

Allosteric Inhibitors, Crystallography, and Comparative Analysis Reveal Network of Coordinated Movement across Human Herpesvirus Proteases.

Acker TM, Gable JE, Bohn MF, Jaishankar P, Thompson MC, Fraser JS, Renslo AR, Craik CS. Acker TM, et al. J Am Chem Soc. 2017 Aug 30;139(34):11650-11653. doi: 10.1021/jacs.7b04030. Epub 2017 Aug 17. J Am Chem Soc. 2017. PMID: 28759216 Free PMC article.

4

Fragment-Based Protein-Protein Interaction Antagonists of a Viral Dimeric Protease.

Gable JE, Lee GM, Acker TM, Hulce KR, Gonzalez ER, Schweigler P, Melkko S, Farady CJ, Craik CS. Gable JE, et al. Among authors: acker tm. ChemMedChem. 2016 Apr 19;11(8):862-9. doi: 10.1002/cmdc.201500526. Epub 2016 Jan 28. ChemMedChem. 2016. PMID: 26822284 Free PMC article.

5

A Novel Negative Allosteric Modulator Selective for GluN2C/2D-Containing NMDA Receptors Inhibits Synaptic Transmission in Hippocampal Interneurons.

Swanger SA, Vance KM, Acker TM, Zimmerman SS, DiRaddo JO, Myers SJ, Bundgaard C, Mosley CA, Summer SL, Menaldino DS, Jensen HS, Liotta DC, Traynelis SF. Swanger SA, et al. Among authors: acker tm. ACS Chem Neurosci. 2018 Feb 21;9(2):306-319. doi: 10.1021/acschemneuro.7b00329. Epub 2017 Nov 2. ACS Chem Neurosci. 2018. PMID: 29043770 Free PMC article.

6

Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-methyl-D-aspartate receptor antagonists.

Mosley CA, Acker TM, Hansen KB, Mullasseril P, Andersen KT, Le P, Vellano KM, Bräuner-Osborne H, Liotta DC, Traynelis SF. Mosley CA, et al. Among authors: acker tm. J Med Chem. 2010 Aug 12;53(15):5476-90. doi: 10.1021/jm100027p. J Med Chem. 2010. PMID: 20684595 Free PMC article.

7

Mechanism for noncompetitive inhibition by novel GluN2C/D N-methyl-D-aspartate receptor subunit-selective modulators.

Acker TM, Yuan H, Hansen KB, Vance KM, Ogden KK, Jensen HS, Burger PB, Mullasseril P, Snyder JP, Liotta DC, Traynelis SF. Acker TM, et al. Mol Pharmacol. 2011 Nov;80(5):782-95. doi: 10.1124/mol.111.073239. Epub 2011 Aug 1. Mol Pharmacol. 2011. PMID: 21807990 Free PMC article.

8

Novel NMDA receptor modulators: an update.

Santangelo RM, Acker TM, Zimmerman SS, Katzman BM, Strong KL, Traynelis SF, Liotta DC. Santangelo RM, et al. Among authors: acker tm. Expert Opin Ther Pat. 2012 Nov;22(11):1337-52. doi: 10.1517/13543776.2012.728587. Epub 2012 Sep 26. Expert Opin Ther Pat. 2012. PMID: 23009122 Free PMC article. Review.

9

Structure-activity relationships and pharmacophore model of a noncompetitive pyrazoline containing class of GluN2C/GluN2D selective antagonists.

Acker TM, Khatri A, Vance KM, Slabber C, Bacsa J, Snyder JP, Traynelis SF, Liotta DC. Acker TM, et al. J Med Chem. 2013 Aug 22;56(16):6434-56. doi: 10.1021/jm400652r. Epub 2013 Aug 2. J Med Chem. 2013. PMID: 23909910 Free PMC article.

10

Modeling the CRL4A ligase complex to predict target protein ubiquitination induced by cereblon-recruiting PROTACs.

Bai N, Riching KM, Makaju A, Wu H, Acker TM, Ou SC, Zhang Y, Shen X, Bulloch DN, Rui H, Gibson BW, Daniels DL, Urh M, Rock BM, Humphreys SC. Bai N, et al. Among authors: acker tm. J Biol Chem. 2022 Apr;298(4):101653. doi: 10.1016/j.jbc.2022.101653. Epub 2022 Jan 29. J Biol Chem. 2022. PMID: 35101445 Free PMC article.

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