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The potential of epigenetic therapy to target the 3D epigenome in endocrine-resistant breast cancer.
Achinger-Kawecka J, Stirzaker C, Portman N, Campbell E, Chia KM, Du Q, Laven-Law G, Nair SS, Yong A, Wilkinson A, Clifton S, Milioli HH, Alexandrou S, Caldon CE, Song J, Khoury A, Meyer B, Chen W, Pidsley R, Qu W, Gee JMW, Schmitt A, Wong ES, Hickey TE, Lim E, Clark SJ. Achinger-Kawecka J, et al. Nat Struct Mol Biol. 2024 Mar;31(3):498-512. doi: 10.1038/s41594-023-01181-7. Epub 2024 Jan 5. Nat Struct Mol Biol. 2024. PMID: 38182927 Free PMC article.
The 2023 generation.
Achinger-Kawecka J, Correa S, Hu J, Li G, Lindeboom RGH, Misale S, Monkkonen T, Nirmal AJ, Prekovic S, Sinha S, Trigos AS, Watson CJ. Achinger-Kawecka J, et al. Nat Cancer. 2023 Dec;4(12):1630-1635. doi: 10.1038/s43018-023-00681-1. Nat Cancer. 2023. PMID: 38102362 No abstract available.
Memory of stochastic single-cell apoptotic signaling promotes chemoresistance in neuroblastoma.
Hastings JF, Latham SL, Kamili A, Wheatley MS, Han JZR, Wong-Erasmus M, Phimmachanh M, Nobis M, Pantarelli C, Cadell AL, O'Donnell YEI, Leong KH, Lynn S, Geng FS, Cui L, Yan S, Achinger-Kawecka J, Stirzaker C, Norris MD, Haber M, Trahair TN, Speleman F, De Preter K, Cowley MJ, Bogdanovic O, Timpson P, Cox TR, Kolch W, Fletcher JI, Fey D, Croucher DR. Hastings JF, et al. Among authors: achinger kawecka j. Sci Adv. 2023 Mar 3;9(9):eabp8314. doi: 10.1126/sciadv.abp8314. Epub 2023 Mar 3. Sci Adv. 2023. PMID: 36867694 Free PMC article.
Epigenetic Therapies and Biomarkers in Breast Cancer.
Brown LJ, Achinger-Kawecka J, Portman N, Clark S, Stirzaker C, Lim E. Brown LJ, et al. Among authors: achinger kawecka j. Cancers (Basel). 2022 Jan 18;14(3):474. doi: 10.3390/cancers14030474. Cancers (Basel). 2022. PMID: 35158742 Free PMC article. Review.
DNA methylation is required to maintain both DNA replication timing precision and 3D genome organization integrity.
Du Q, Smith GC, Luu PL, Ferguson JM, Armstrong NJ, Caldon CE, Campbell EM, Nair SS, Zotenko E, Gould CM, Buckley M, Chia KM, Portman N, Lim E, Kaczorowski D, Chan CL, Barton K, Deveson IW, Smith MA, Powell JE, Skvortsova K, Stirzaker C, Achinger-Kawecka J, Clark SJ. Du Q, et al. Among authors: achinger kawecka j. Cell Rep. 2021 Sep 21;36(12):109722. doi: 10.1016/j.celrep.2021.109722. Cell Rep. 2021. PMID: 34551299 Free article.
Epigenetic reprogramming at estrogen-receptor binding sites alters 3D chromatin landscape in endocrine-resistant breast cancer.
Achinger-Kawecka J, Valdes-Mora F, Luu PL, Giles KA, Caldon CE, Qu W, Nair S, Soto S, Locke WJ, Yeo-Teh NS, Gould CM, Du Q, Smith GC, Ramos IR, Fernandez KF, Hoon DS, Gee JMW, Stirzaker C, Clark SJ. Achinger-Kawecka J, et al. Nat Commun. 2020 Jan 16;11(1):320. doi: 10.1038/s41467-019-14098-x. Nat Commun. 2020. PMID: 31949157 Free PMC article.
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