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Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy.
Belaidi AA, Masaldan S, Southon A, Kalinowski P, Acevedo K, Appukuttan AT, Portbury S, Lei P, Agarwal P, Leurgans SE, Schneider J, Conrad M, Bush AI, Ayton S. Belaidi AA, et al. Among authors: acevedo k. Mol Psychiatry. 2022 Apr 28:10.1038/s41380-022-01568-w. doi: 10.1038/s41380-022-01568-w. Online ahead of print. Mol Psychiatry. 2022. PMID: 35484240 Free PMC article.
Selective ferroptosis vulnerability due to familial Alzheimer's disease presenilin mutations.
Greenough MA, Lane DJR, Balez R, Anastacio HTD, Zeng Z, Ganio K, McDevitt CA, Acevedo K, Belaidi AA, Koistinaho J, Ooi L, Ayton S, Bush AI. Greenough MA, et al. Among authors: acevedo k. Cell Death Differ. 2022 Nov;29(11):2123-2136. doi: 10.1038/s41418-022-01003-1. Epub 2022 Apr 21. Cell Death Differ. 2022. PMID: 35449212 Free PMC article.
Redox active metals in neurodegenerative diseases.
Acevedo K, Masaldan S, Opazo CM, Bush AI. Acevedo K, et al. J Biol Inorg Chem. 2019 Dec;24(8):1141-1157. doi: 10.1007/s00775-019-01731-9. Epub 2019 Oct 24. J Biol Inorg Chem. 2019. PMID: 31650248 Review.
Copper promotes the trafficking of the amyloid precursor protein.
Acevedo KM, Hung YH, Dalziel AH, Li QX, Laughton K, Wikhe K, Rembach A, Roberts B, Masters CL, Bush AI, Camakaris J. Acevedo KM, et al. J Biol Chem. 2011 Mar 11;286(10):8252-8262. doi: 10.1074/jbc.M110.128512. Epub 2010 Dec 22. J Biol Chem. 2011. PMID: 21177866 Free PMC article.
TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway.
Moujalled D, Grubman A, Acevedo K, Yang S, Ke YD, Moujalled DM, Duncan C, Caragounis A, Perera ND, Turner BJ, Prudencio M, Petrucelli L, Blair I, Ittner LM, Crouch PJ, Liddell JR, White AR. Moujalled D, et al. Among authors: acevedo k. Hum Mol Genet. 2017 May 1;26(9):1732-1746. doi: 10.1093/hmg/ddx093. Hum Mol Genet. 2017. PMID: 28334913
Effect of Structural Modifications to Glyoxal-bis(thiosemicarbazonato)copper(II) Complexes on Cellular Copper Uptake, Copper-Mediated ATP7A Trafficking, and P-Glycoprotein Mediated Efflux.
Acevedo KM, Hayne DJ, McInnes LE, Noor A, Duncan C, Moujalled D, Volitakis I, Rigopoulos A, Barnham KJ, Villemagne VL, White AR, Donnelly PS. Acevedo KM, et al. J Med Chem. 2018 Feb 8;61(3):711-723. doi: 10.1021/acs.jmedchem.7b01158. Epub 2018 Jan 8. J Med Chem. 2018. PMID: 29232129
LIM kinase 2 is widely expressed in all tissues.
Acevedo K, Moussi N, Li R, Soo P, Bernard O. Acevedo K, et al. J Histochem Cytochem. 2006 May;54(5):487-501. doi: 10.1369/jhc.5C6813.2006. Epub 2006 Jan 6. J Histochem Cytochem. 2006. PMID: 16399995
41 results